Adipose tatty acid composition and gene expression in obesity, and response to chronic marine omega-3 fatty acid supplementation

• Published in: Proceedings of the Nutrition Society Vol. 79; no. OCE2
• Main Authors: Fisk, Helena, Ayres, Rob, Childs, Caroline, Miles, Elizabeth, Clarke-Harris, Rebecca, Lillycrop, Karen, Calder, Philip
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 2020
• Subjects: Adipose tissue; Amino acids; Cardiovascular diseases; Cell activation; Cell growth; Cell proliferation; complement; Complement activation; Composition; Corn oil; Cyclooxygenase-2; Diabetes mellitus; Fatty acid composition; Fatty acids; Gas chromatography; Gene expression; gene expression regulation; Gene sequencing; Genes; glucose; Glucose transport; Immune response; Immune system; immunoglobulins; Inflammation; Inflammatory response; Lipid metabolism; Lipids; Liquid oxygen; Matrilysin; Metabolites; noninsulin-dependent diabetes mellitus; Nutrient transport; Obesity; Oils & fats; Omega-3 fatty acids; Ribonucleic acid; risk; RNA; secretion; sequence analysis; Signal transduction; Supplements; Transcription; transcriptome; Weight; Wnt protein; wnt proteins

Introduction:Obesity is an excess of adipose tissue (AT) and is linked with increased inflammation that enhances risk of type-2 diabetes and cardiovascular disease. The BIOCLAIMS study assessed the effect of obesity on AT fatty acid composition and gene expression, and the responses of these to chro...