Impaired T‐Amplitude Adaptation to Heart Rate Characterizes I Kr Inhibition in the Congenital and Acquired Forms of the Long QT Syndrome
Introduction: The QTc interval prolongation is not a perfect surrogate marker of the presence of an increased risk for arrhythmic events. In the search for alternative markers, we investigated the T‐amplitude and QT interval adaptation to heart rate (HR) in patients with the congenital long QT synd...
Saved in:
Published in | Journal of cardiovascular electrophysiology Vol. 18; no. 12; pp. 1299 - 1305 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.12.2007
|
Online Access | Get full text |
Cover
Loading…
Abstract | Introduction:
The QTc interval prolongation is not a perfect surrogate marker of the presence of an increased risk for arrhythmic events. In the search for alternative markers, we investigated the T‐amplitude and QT interval adaptation to heart rate (HR) in patients with the congenital long QT syndrome (LQTS) and individuals with sotalol‐induced QT prolongation.
Methods and Results:
Our investigation is based on the analysis of continuous 12‐lead digital Holter recordings in: 49 LQT1 carriers, 25 LQT2 carriers, 37 healthy individuals off drugs and on 160 mg of sotalol, and 21 of them also on 320 mg of sotalol. The Holter recordings were used to investigate repolarization parameters and their HR dependency. A loss of HR dependency of the T‐amplitude was found as a common feature in individuals with impaired I
kr
kinetics: LQT2 carriers and subjects on sotalol. The T‐amplitude/RR slope was significantly (P < 0.05) flatter in LQT2 (0.31 ± 0.27 μV/ms) than in both LQT1 (0.62 ± 0.40 μV/ms) and healthy individuals (0.55 ± 0.29 μV/ms). A dose‐dependent reduction of the T‐amplitude/RR slope was also observed in subjects on sotalol (160 mg dose: 0.26 ± 0.19 μV/ms; 320 mg dose: 0.21 ± 0.14 μV/ms). The QT/RR slope was less effective than T‐amplitude/RR slope in differentiating between congenital and drug‐induced repolarization delay.
Conclusions:
Impaired adaptation of T‐amplitude to changing HR is a common electrocardiographic feature associated with KCNH2 mutation and I
kr
blockade by sotalol. This ECG marker may play an important role in the future of the assessment of the penetrance of KCNH2 mutation and the identification of a drug effect on the I
kr
kinetics. |
---|---|
AbstractList | Introduction:
The QTc interval prolongation is not a perfect surrogate marker of the presence of an increased risk for arrhythmic events. In the search for alternative markers, we investigated the T‐amplitude and QT interval adaptation to heart rate (HR) in patients with the congenital long QT syndrome (LQTS) and individuals with sotalol‐induced QT prolongation.
Methods and Results:
Our investigation is based on the analysis of continuous 12‐lead digital Holter recordings in: 49 LQT1 carriers, 25 LQT2 carriers, 37 healthy individuals off drugs and on 160 mg of sotalol, and 21 of them also on 320 mg of sotalol. The Holter recordings were used to investigate repolarization parameters and their HR dependency. A loss of HR dependency of the T‐amplitude was found as a common feature in individuals with impaired I
kr
kinetics: LQT2 carriers and subjects on sotalol. The T‐amplitude/RR slope was significantly (P < 0.05) flatter in LQT2 (0.31 ± 0.27 μV/ms) than in both LQT1 (0.62 ± 0.40 μV/ms) and healthy individuals (0.55 ± 0.29 μV/ms). A dose‐dependent reduction of the T‐amplitude/RR slope was also observed in subjects on sotalol (160 mg dose: 0.26 ± 0.19 μV/ms; 320 mg dose: 0.21 ± 0.14 μV/ms). The QT/RR slope was less effective than T‐amplitude/RR slope in differentiating between congenital and drug‐induced repolarization delay.
Conclusions:
Impaired adaptation of T‐amplitude to changing HR is a common electrocardiographic feature associated with KCNH2 mutation and I
kr
blockade by sotalol. This ECG marker may play an important role in the future of the assessment of the penetrance of KCNH2 mutation and the identification of a drug effect on the I
kr
kinetics. |
Author | MOSS, ARTHUR J. WICKER, PIERRE VAGLIO, MARTINO COUDERC, JEAN‐PHILIPPE MCNITT, SCOTT XIA, XIAJUAN SARAPA, NENAD ZAREBA, WOJCIECH |
Author_xml | – sequence: 1 givenname: JEAN‐PHILIPPE surname: COUDERC fullname: COUDERC, JEAN‐PHILIPPE – sequence: 2 givenname: MARTINO surname: VAGLIO fullname: VAGLIO, MARTINO – sequence: 3 givenname: XIAJUAN surname: XIA fullname: XIA, XIAJUAN – sequence: 4 givenname: SCOTT surname: MCNITT fullname: MCNITT, SCOTT – sequence: 5 givenname: PIERRE surname: WICKER fullname: WICKER, PIERRE – sequence: 6 givenname: NENAD surname: SARAPA fullname: SARAPA, NENAD – sequence: 7 givenname: ARTHUR J. surname: MOSS fullname: MOSS, ARTHUR J. – sequence: 8 givenname: WOJCIECH surname: ZAREBA fullname: ZAREBA, WOJCIECH |
BookMark | eNo9kNFKwzAUhoNMcE7fIS_QetI0aXtZhnPFgajzOqRt6jLWZKYZbF557ZXP6JPYVvFw4PxwPs6B7xJNjDUKIUwgJH3dbEPCYghSwpMwAkhCgIxDeDxD0__FpM8Qs4CmCb1Al123BSCUA5uiz6LdS-1UjdffH195u99pf6gVzmu599Jra7C3eKmk8_hJeoXnG-lk5ZXT76rDBb53uDAbXeqR1T2-6SFrXpXRXu6wNDXOq7fD-GNhXdth24zQqofw4xo_n0ztbKuu0Hkjd526_psz9LK4Xc-Xwerhrpjnq6AiaeaDhvOIpZQAQNywmFWyrCLgVHJICOFZlEHTdxnRqGGNTKmqoWSc0F4MsCylM5T-3q2c7TqnGrF3upXuJAiIwanYikGdGNSJwakYnYoj_QF-2G1s |
CitedBy_id | crossref_primary_10_1016_j_ahj_2018_02_014 crossref_primary_10_1016_j_jelectrocard_2017_03_014 crossref_primary_10_1113_jphysiol_2013_251710 crossref_primary_10_1016_j_jelectrocard_2010_07_009 crossref_primary_10_1038_clpt_2010_51 crossref_primary_10_1038_bjp_2008_123 crossref_primary_10_2165_11599270_000000000_00000 crossref_primary_10_1111_j_1542_474X_2010_00402_x crossref_primary_10_1111_anec_12455 crossref_primary_10_1111_anec_12016 crossref_primary_10_1161_JAHA_114_001615 crossref_primary_10_1111_pace_12746 crossref_primary_10_1098_rsta_2008_0284 crossref_primary_10_1111_anec_12878 crossref_primary_10_1007_s10557_015_6619_0 crossref_primary_10_1016_j_jelectrocard_2008_06_013 crossref_primary_10_1111_j_1542_474X_2011_00444_x crossref_primary_10_1016_j_hrthm_2010_08_022 crossref_primary_10_1016_j_jelectrocard_2009_06_019 crossref_primary_10_1007_s00380_016_0859_1 crossref_primary_10_1007_s10840_010_9500_x crossref_primary_10_1016_j_jccase_2020_07_012 crossref_primary_10_1111_j_1542_474X_2009_00336_x crossref_primary_10_1016_j_jacc_2010_02_018 crossref_primary_10_1289_ehp_0800046 crossref_primary_10_1002_jcph_779 crossref_primary_10_1007_s11517_021_02401_2 crossref_primary_10_1016_j_ahj_2012_02_023 crossref_primary_10_1161_CIRCEP_111_969717 crossref_primary_10_1016_j_jelectrocard_2020_08_016 crossref_primary_10_1016_j_jelectrocard_2008_07_021 crossref_primary_10_1016_j_jelectrocard_2008_07_020 crossref_primary_10_1016_j_hrthm_2007_08_026 crossref_primary_10_1016_j_jelectrocard_2015_10_002 crossref_primary_10_1016_j_jelectrocard_2021_07_016 crossref_primary_10_3389_fphys_2016_00154 crossref_primary_10_1016_j_cpcardiol_2008_07_002 |
Cites_doi | 10.1007/BF02513269 10.1023/A:1007759500274 10.1161/01.RES.72.1.75 10.1111/j.1542-474X.2004.91546.x 10.1007/978-1-4899-3242-6 10.1161/hc2601.091738 10.1161/01.CIR.6.3.378 10.1161/01.CIR.85.5.1816 10.1111/j.1542-474X.2005.00593.x 10.1088/0967-3334/23/2/311 10.1136/hrt.71.4.386 10.1097/00001573-200201000-00007 10.1073/pnas.93.5.2208 10.1073/pnas.210244497 10.1161/01.CIR.99.17.2290 10.1124/jpet.105.095471 10.1016/j.hrthm.2006.08.009 10.1046/j.1540-8167.2003.02431.x 10.1074/jbc.274.15.10113 10.1046/j.1460-9592.2002.01230.x 10.1053/euhj.1997.0730 10.1046/j.1540-8167.2004.03096.x 10.1111/j.1540-8159.1998.tb00150.x 10.1161/01.CIR.96.5.1551 10.1161/01.RES.0000016960.61087.86 |
ContentType | Journal Article |
DBID | AAYXX CITATION |
DOI | 10.1111/j.1540-8167.2007.00960.x |
DatabaseName | CrossRef |
DatabaseTitle | CrossRef |
DatabaseTitleList | CrossRef |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology Biology |
EISSN | 1540-8167 |
EndPage | 1305 |
ExternalDocumentID | 10_1111_j_1540_8167_2007_00960_x |
GroupedDBID | --- .3N .GA .GJ .Y3 04C 05W 0R~ 10A 1OB 1OC 29K 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 6PF 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAWTL AAXRX AAYXX AAZKR ABCQN ABCUV ABDBF ABEML ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOJX ADOZA ADXAS ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHEFC AHMBA AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ATUGU AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMSDO BMXJE BPMNR BROTX BRXPI BY8 C45 CAG CITATION COF CS3 D-6 D-7 D-E D-F D-I DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EAD EAP EAS EBC EBD EBS ECF ECT ECV EIHBH EJD EMB EMK EMOBN ENC EPT ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 Q~Q R.K RIWAO ROL RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 V8K VVN W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQ9 WQJ WRC WUP WVDHM WXI WXSBR XG1 ZGI ZXP ZZTAW ~IA ~WT |
ID | FETCH-LOGICAL-c189t-f66258310004f545cabc2063a6071169290f90fb232f5fa83ed0b561300905983 |
ISSN | 1045-3873 |
IngestDate | Fri Aug 23 01:37:02 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 12 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c189t-f66258310004f545cabc2063a6071169290f90fb232f5fa83ed0b561300905983 |
PageCount | 7 |
ParticipantIDs | crossref_primary_10_1111_j_1540_8167_2007_00960_x |
PublicationCentury | 2000 |
PublicationDate | 2007-12-00 |
PublicationDateYYYYMMDD | 2007-12-01 |
PublicationDate_xml | – month: 12 year: 2007 text: 2007-12-00 |
PublicationDecade | 2000 |
PublicationTitle | Journal of cardiovascular electrophysiology |
PublicationYear | 2007 |
References | e_1_2_6_18_2 e_1_2_6_19_2 e_1_2_6_12_2 e_1_2_6_13_2 e_1_2_6_10_2 e_1_2_6_11_2 e_1_2_6_16_2 e_1_2_6_17_2 e_1_2_6_14_2 e_1_2_6_15_2 e_1_2_6_20_2 Antzelevitch C (e_1_2_6_6_2) 2001 e_1_2_6_8_2 e_1_2_6_7_2 e_1_2_6_9_2 e_1_2_6_29_2 e_1_2_6_4_2 e_1_2_6_3_2 e_1_2_6_5_2 e_1_2_6_24_2 e_1_2_6_23_2 e_1_2_6_2_2 e_1_2_6_22_2 e_1_2_6_21_2 e_1_2_6_28_2 e_1_2_6_27_2 e_1_2_6_26_2 e_1_2_6_25_2 |
References_xml | – ident: e_1_2_6_16_2 doi: 10.1007/BF02513269 – ident: e_1_2_6_28_2 doi: 10.1023/A:1007759500274 – ident: e_1_2_6_21_2 doi: 10.1161/01.RES.72.1.75 – ident: e_1_2_6_13_2 doi: 10.1111/j.1542-474X.2004.91546.x – ident: e_1_2_6_17_2 doi: 10.1007/978-1-4899-3242-6 – ident: e_1_2_6_24_2 doi: 10.1161/hc2601.091738 – ident: e_1_2_6_15_2 doi: 10.1161/01.CIR.6.3.378 – ident: e_1_2_6_19_2 doi: 10.1161/01.CIR.85.5.1816 – ident: e_1_2_6_14_2 doi: 10.1111/j.1542-474X.2005.00593.x – ident: e_1_2_6_22_2 doi: 10.1088/0967-3334/23/2/311 – ident: e_1_2_6_29_2 doi: 10.1136/hrt.71.4.386 – ident: e_1_2_6_12_2 doi: 10.1097/00001573-200201000-00007 – ident: e_1_2_6_2_2 doi: 10.1073/pnas.93.5.2208 – ident: e_1_2_6_3_2 doi: 10.1073/pnas.210244497 – ident: e_1_2_6_5_2 doi: 10.1161/01.CIR.99.17.2290 – ident: e_1_2_6_10_2 doi: 10.1124/jpet.105.095471 – start-page: 654 volume-title: Handbook of Physiology. The Heart year: 2001 ident: e_1_2_6_6_2 contributor: fullname: Antzelevitch C – ident: e_1_2_6_7_2 doi: 10.1016/j.hrthm.2006.08.009 – ident: e_1_2_6_8_2 doi: 10.1046/j.1540-8167.2003.02431.x – ident: e_1_2_6_4_2 doi: 10.1074/jbc.274.15.10113 – ident: e_1_2_6_23_2 doi: 10.1046/j.1460-9592.2002.01230.x – ident: e_1_2_6_11_2 doi: 10.1073/pnas.93.5.2208 – ident: e_1_2_6_18_2 doi: 10.1053/euhj.1997.0730 – ident: e_1_2_6_20_2 doi: 10.1046/j.1540-8167.2004.03096.x – ident: e_1_2_6_26_2 doi: 10.1111/j.1540-8159.1998.tb00150.x – ident: e_1_2_6_27_2 doi: 10.1111/j.1540-8159.1998.tb00150.x – ident: e_1_2_6_9_2 doi: 10.1161/01.CIR.96.5.1551 – ident: e_1_2_6_25_2 doi: 10.1161/01.RES.0000016960.61087.86 |
SSID | ssj0013605 |
Score | 2.1136155 |
Snippet | Introduction:
The QTc interval prolongation is not a perfect surrogate marker of the presence of an increased risk for arrhythmic events. In the search for... |
SourceID | crossref |
SourceType | Aggregation Database |
StartPage | 1299 |
Title | Impaired T‐Amplitude Adaptation to Heart Rate Characterizes I Kr Inhibition in the Congenital and Acquired Forms of the Long QT Syndrome |
Volume | 18 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFLaqIRAXBBuI33oHxKUKStokjY8h22jG1m4lRb1VSRprPdBMW3pgJ86c-Bv5H7jznh27CVT8mFSlkZu4Td9n-3vPn58Ze1UsyAtIbWuR2oHlCuFa3OcCiRzyA5-7vKfUFiN_OHWPZt6s0_nRUC2tq-xNfr11XclNrIplaFdaJfsfljWVYgGeo33xiBbG4z_ZOMa2vCQBeWI0CyEpxClfZTdcpBe1lBD55RARXXUnyCzlDLvK0XxdXHVjbOfYS5wvs2VT9xiVtOiKdhSR0wthToph_KZD5LhXWlhwTBsVnSXdD1vSHjSYbt7WvNY778iYSiuoH42n-weTSCUADUfmmU6HMcUfzJqJj-G743gsQ7lIx-PRWH8wi0MqxbejaWjmmE6iUZwkMsxLAYxWnGPQ0IyorhnJJ2UCVt1hUXfXrm0FjtrQ4_f-fG002qp3Rm7DGyM9Dt_en0cRXb1OdYnunlaXNhN3_zKgGpljw8HCmuZUE237STP-WBO5Prd6A-5RzGB_0ttMfqnlvOaB2wK0rb-pwaoa9Ci5z-7V1oZQgfQB6xSrXbYXrtKq_PQZXsOpsfYuu_1Wn905qaUde-yrBjMk3798MzCGDYyhKkHCGAjG0IIxxPD-EjYwhiVefo4XGRgDwhg0jEHCGEohLyIYw1kCGsYP2fTwIImGVr1RiJU7Aa8s4aMXH8ipKlegS5CnWd5D7p1S8kTHRw_AFvjK0HsQnkiDfrGwM-k52xzdi6D_iO2sylXxmAGya5cLp_C4dNVxwHO546Vp384GIsv7T5ij_-j5hcoHM_-bmZ_e4J5n7O6mETxnO9XluniB9LfKXkqw_ARRc6Mg |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Wiley-Blackwell |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Impaired+T%E2%80%90Amplitude+Adaptation+to+Heart+Rate+Characterizes+I+Kr+Inhibition+in+the+Congenital+and+Acquired+Forms+of+the+Long+QT+Syndrome&rft.jtitle=Journal+of+cardiovascular+electrophysiology&rft.au=COUDERC%2C+JEAN%E2%80%90PHILIPPE&rft.au=VAGLIO%2C+MARTINO&rft.au=XIA%2C+XIAJUAN&rft.au=MCNITT%2C+SCOTT&rft.date=2007-12-01&rft.issn=1045-3873&rft.eissn=1540-8167&rft.volume=18&rft.issue=12&rft.spage=1299&rft.epage=1305&rft_id=info:doi/10.1111%2Fj.1540-8167.2007.00960.x&rft.externalDBID=n%2Fa&rft.externalDocID=10_1111_j_1540_8167_2007_00960_x |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1045-3873&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1045-3873&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1045-3873&client=summon |