Enhanced levels of prostaglandin E 2 and matrix metalloproteinase‐2 correlate with the severity of airflow limitation in stable COPD

• Published in: Respirology (Carlton, Vic.) Vol. 13; no. 7; pp. 1014 - 1021
• Main Authors: CHEN, Yan, CHEN, Ping, HANAOKA, Masayuki, DROMA, Yunden, KUBO, Keishi
• Format: Journal Article
• Language: English
• Published: 01.11.2008

Background and objective:  Cyclooxygenase‐2 (COX‐2) and its product prostaglandin E 2 (PGE 2 ) have been demonstrated to play critical roles in inflammation in respiratory diseases. However, the role of COX‐2 in airway remodelling in COPD remains to be elucidated. Matrix metalloproteinase‐2 (MMP‐2)...