Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity

• Published in: Nature cell biology Vol. 26; no. 8; pp. 1346 - 1358
• Main Authors: Shi, Rong-Yi, Zhou, Neng, Xuan, Li, Jiang, Zhong-Hui, Xia, Jing, Zhu, Jian-Min, Chen, Kai-Ming, Zhou, Guo-Li, Yu, Guo-Pan, Zhang, Jun, Huang, Chuanxin, Liang, Ai-Bin, Liang, Kai-Wei, Zhang, Hao, Chen, Jian-Feng, Zhang, Dachuan, Zhong, Yi, Liu, Qi-Fa, Chen, Guo-Qiang, Duan, Cai-Wen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.08.2024
• Subjects: Animal models; Anticancer properties; Antitumor activity; Bone marrow; CD44 antigen; CD8 antigen; Cell adhesion; Cell adhesion molecules; Cell culture; Chemokine receptors; Chemokines; Chemotherapy; Immune response; Immune system; Immunity; Immunogenicity; Immunological memory; Immunotherapy; Intestine; L-selectin; Leukemia; Lymphocytes; Lymphocytes T; Memory cells; Small intestine; Vascular cell adhesion molecule 1
• ISSN: 1465-7392; 1476-4679; 1476-4679
• DOI: 10.1038/s41556-024-01462-3

Immunotherapy elicits a systemic antitumour immune response in peripheral circulating T cells. However, the T cell trafficking circuit between organs and their contributions to antitumour immunity remain largely unknown. Here we show in multiple mouse leukaemia models that high infiltration of leukaemic cells in bone marrow (BM) stimulates the transition of CD8+CD44+CD62L+ central memory T cells into CD8+CD44–CD62L– T cells, designated as inter-organ migratory T cells (TIM cells). TIM cells move from the BM to the intestine by upregulating integrin β7 and downregulating C-X-C motif chemokine receptor 3 during leukaemogenesis. Upon immunogenic chemotherapy, these BM-derived TIM cells return from the intestine to the BM through integrin α4–vascular cell adhesion molecule 1 interaction. Blocking C-X-C motif chemokine receptor 3 function boosts the immune response against leukaemia by enhancing T cell trafficking. This phenomenon can also be observed in patients with leukaemia. In summary, we identify an unrecognized intestine–BM trafficking circuit of T cells that contributes to the antitumour effects of immunogenic chemotherapy.Shi, Zhou, Xuan, Jiang et al. identify a population of CD8+ T cells that migrate from bone marrow to the small intestine during leukaemogenesis and then traffic back to contribute to anti-leukaemia immune responses during chemotherapy treatment.