SCN 1Bβ mutations that affect their association with Kv4.3 underlie early repolarization syndrome

• Published in: Journal of cellular and molecular medicine Vol. 22; no. 11; pp. 5639 - 5647
• Main Authors: Yao, Hao, Fan, Jun, Cheng, Yun‐Jiu, Chen, Xu‐Miao, Ji, Cheng‐Cheng, Liu, Li‐Juan, Zheng, Zi‐Heng, Wu, Su‐Hua
• Format: Journal Article
• Language: English
• Published: Chichester John Wiley & Sons, Inc 01.11.2018
• Subjects: Immunoprecipitation; Ion channels; Mutation; Phenotypes; Potassium; Potassium channels (voltage-gated)

BackgroundAbnormal cardiac ion channels current, including transient outward potassium current (Ito), is associated with early repolarization syndrome (ERS). Previous studies showed that mutations in SCN1Bβ both to increase the Ito current and to decrease the sodium current. Yet its role in ERS rema...