Towards cascading genetic risk in Alzheimer's disease

• Published in: Brain (London, England : 1878) Vol. 147; no. 8; pp. 2680 - 2690
• Main Authors: Altmann, Andre, Aksman, Leon M, Oxtoby, Neil P, Young, Alexandra L, Alexander, Daniel C, Barkhof, Frederik, Shoai, Maryam, Hardy, John, Schott, Jonathan M
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.08.2024
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - genetics; Amyloid beta-Peptides - cerebrospinal fluid; Apolipoproteins E - genetics; Biomarkers - cerebrospinal fluid; Cohort Studies; Disease Progression; Female; Genetic Predisposition to Disease - genetics; Genome-Wide Association Study; Humans; Male; Middle Aged; Multifactorial Inheritance - genetics; Original; Positron-Emission Tomography; tau Proteins - cerebrospinal fluid; tau Proteins - genetics; longitudinal progression; APOE; Alzheimer’s disease; biomarker; polygenic risk

Alzheimer's disease typically progresses in stages, which have been defined by the presence of disease-specific biomarkers: amyloid (A), tau (T) and neurodegeneration (N). This progression of biomarkers has been condensed into the ATN framework, in which each of the biomarkers can be either pos...