Spinal epidural hematoma following coronary thrombolysis with tissue plasminogen activator. Report of two cases

Two cases of spinal epidural hematoma following intravenous administration of recombinant tissue-type plasminogen activator are presented. Both patients received thrombolytic therapy for acute myocardial infarction; back pain and progressive neurological dysfunction ensued, secondary to spinal cord...

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Bibliographic Details
Published inJournal of neurosurgery Vol. 83; no. 2; p. 350
Main Authors Sawin, P D, Traynelis, V C, Follett, K A
Format Journal Article
LanguageEnglish
Published United States 01.08.1995
Subjects
Aged
Female
Hematoma, Epidural, Cranial - chemically induced
Humans
Hypesthesia - etiology
Injections, Intravenous
Middle Aged
Myocardial Infarction - drug therapy
Paraplegia - etiology
Spinal Cord Compression - etiology
Thrombolytic Therapy - adverse effects
Tissue Plasminogen Activator - administration & dosage
Tissue Plasminogen Activator - adverse effects
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Summary:Two cases of spinal epidural hematoma following intravenous administration of recombinant tissue-type plasminogen activator are presented. Both patients received thrombolytic therapy for acute myocardial infarction; back pain and progressive neurological dysfunction ensued, secondary to spinal cord compression caused by epidural hematoma. Both individuals underwent emergency surgery for decompression and hematoma evacuation, resulting in improvement in neurological function. The current status of thrombolytic therapy is reviewed, with emphasis on complications of therapy that require neurosurgical intervention.
ISSN:0022-3085
DOI:10.3171/jns.1995.83.2.0350