Investigation of solvents that can be used as vehicles to evaluate poorly soluble compounds in short-term oral toxicity studies in rats

• Published in: Fundamental Toxicological Sciences Vol. 11; no. 2; pp. 69 - 78
• Main Authors: Ikeda, Keigo, Kochi, Mami, Tochitani, Tomoaki, Umeya, Naohisa, Matsumoto, Izumi, Fujii, Yuta, Usui, Toru, Miyawaki, Izuru
• Format: Journal Article
• Language: English
• Published: The Japanese Society of Toxicology 2024
• Subjects: NOEL; Oral toxicity study; Poorly soluble compound; Rat; Vehicle

In non-clinical toxicity studies of orally dosed small molecule drugs, methyl cellulose (MC) is commonly used as the vehicle. It is well tolerated and easy to prepare. However, it is not suitable as the vehicle for all poorly soluble compounds. The objective of this study was to evaluate the no-obse...