Brief introduction to current pharmacogenomics research tools

There is increasing interest in the application of personalized therapy to healthcare to increase the effectiveness of and reduce the adverse reactions to treatment. Pharmacogenomics is a core element in personalized therapy and pharmacogenomic research is a growing field. Understanding pharmacogeno...

Full description

Saved in:
Bibliographic Details
Published inTranslational and clinical pharmacology Vol. 24; no. 1; pp. 13 - 21
Main Authors Cha, Eun-Young, Jeong, Hye-Eun, Kim, Woo-Young, Shin, Ho Jung, Kim, Ho-Sook, Shin, Jae-Gook
Format Journal Article
LanguageEnglish
Published 대한임상약리학회 2016
Subjects
의약학
Online AccessGet full text
ISSN2289-0882
2383-5427
DOI10.12793/tcp.2016.24.1.13

Cover

Abstract There is increasing interest in the application of personalized therapy to healthcare to increase the effectiveness of and reduce the adverse reactions to treatment. Pharmacogenomics is a core element in personalized therapy and pharmacogenomic research is a growing field. Understanding pharmacogenomic research tools enables better design, conduct, and analysis of pharmacogenomic stud¬ies, as well as interpretation of pharmacogenomic results. This review provides a general and brief introduction to pharmacogenomics research tools, including genotyping technology, web-based genome browsers, and software for haplotype analysis. KCI Citation Count: 0
AbstractList There is increasing interest in the application of personalized therapy to healthcare to increase the effectiveness of and reduce the adverse reactions to treatment. Pharmacogenomics is a core element in personalized therapy and pharmacogenomic research is a growing field. Understanding pharmacogenomic research tools enables better design, conduct, and analysis of pharmacogenomic stud¬ies, as well as interpretation of pharmacogenomic results. This review provides a general and brief introduction to pharmacogenomics research tools, including genotyping technology, web-based genome browsers, and software for haplotype analysis. KCI Citation Count: 0
Author Cha, Eun-Young
Kim, Ho-Sook
Jeong, Hye-Eun
Kim, Woo-Young
Shin, Jae-Gook
Shin, Ho Jung
Author_xml – sequence: 1
  givenname: Eun-Young
  surname: Cha
  fullname: Cha, Eun-Young
  organization: Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 47392, Korea
– sequence: 2
  givenname: Hye-Eun
  surname: Jeong
  fullname: Jeong, Hye-Eun
  organization: Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 47392, Korea
– sequence: 3
  givenname: Woo-Young
  surname: Kim
  fullname: Kim, Woo-Young
  organization: Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 47392, Korea
– sequence: 4
  givenname: Ho Jung
  surname: Shin
  fullname: Shin, Ho Jung
  organization: Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 47392, Korea
– sequence: 5
  givenname: Ho-Sook
  surname: Kim
  fullname: Kim, Ho-Sook
  organization: Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 47392, Korea., Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan 47392, Korea
– sequence: 6
  givenname: Jae-Gook
  surname: Shin
  fullname: Shin, Jae-Gook
  organization: Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 47392, Korea., Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan 47392, Korea
BackLink https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002091292$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNotkE1PAjEURRuDiYj8AHezdDNjX19pOwsXSPwgITExuG5KpwMVpiXtsPDfO4KrexcnL--eWzIKMThC7oFWwGSNj709VoyCqBivoAK8ImOGCssZZ3I0dKbqkirFbsg0529KKSBHEHRMnp6Td23hQ59ic7K9j6HoY2FPKbnQF8edSZ2xcetC7LzNRXLZmWR3AxQP-Y5ct-aQ3fQ_J-Tr9WW9eC9XH2_LxXxVWlDDG1LVTWulkkipkZuNYy3nYEUthbBMKWVow8SMgRNoKHA0kqIwpmHUNFI2OCEPl7shtXpvvY7Gn3Mb9T7p-ed6qYc5yNWAwgW1KeacXKuPyXcm_Wig-mxLD7b0ny3NuAYNiL-ptl7Z
Cites_doi 10.1093/nar/gku1177
10.1007/s00439-014-1484-7
10.1086/319501
10.1093/oxfordjournals.jhered.a111613
10.1128/JCM.01209-06
10.1016/j.drudis.2011.08.008
10.1038/nrd1496
10.1101/gr.11.1.3
10.1086/338446
10.1093/bib/bbs029
10.1186/1471-2105-10-348
10.1086/379378
10.1038/nrd705
10.1056/NEJMicm1001885
10.1086/428594
10.1038/nature11632
10.1099/jmm.0.055905-0
10.1016/S0076-6879(06)10001-4
10.1016/0888-7543(88)90088-2
10.1186/1471-2164-11-295
10.1186/1756-0500-2-66
10.1093/nar/gkt1196
10.1093/nar/gkt1113
10.1086/519795
10.1007/s11032-015-0335-0
10.1086/339271
10.1146/annurev.bioeng.9.060906.152037
10.1042/BST0370454
10.1093/bioinformatics/bth457
10.1101/pdb.ip71
10.1038/nature04226
10.1016/S1074-5521(02)00266-1
10.1038/nature02168
10.1086/302577
ContentType Journal Article
DBID AAYXX
CITATION
ACYCR
DOI 10.12793/tcp.2016.24.1.13
DatabaseName CrossRef
Korean Citation Index
DatabaseTitle CrossRef
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
EISSN 2383-5427
EndPage 21
ExternalDocumentID oai_kci_go_kr_ARTI_160348
10_12793_tcp_2016_24_1_13
GroupedDBID 5-W
8JR
8XY
AAYXX
ABDBF
ACUHS
ALMA_UNASSIGNED_HOLDINGS
CITATION
EF.
PGMZT
RPM
ACYCR
ID FETCH-LOGICAL-c1883-789dfc787300a7bbe2f441c69766c2888a0d26521e63a0143a7036aad20ad77d3
ISSN 2289-0882
IngestDate Sun Mar 09 07:51:18 EDT 2025
Tue Jul 01 01:24:03 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed false
IsScholarly true
Issue 1
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c1883-789dfc787300a7bbe2f441c69766c2888a0d26521e63a0143a7036aad20ad77d3
Notes G704-002229.2016.24.1.004
OpenAccessLink http://synapse.koreamed.org/Synapse/Data/PDFData/1179TCP/tcp-24-13.pdf
PageCount 9
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_160348
crossref_primary_10_12793_tcp_2016_24_1_13
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2016-00-00
PublicationDateYYYYMMDD 2016-01-01
PublicationDate_xml – year: 2016
  text: 2016-00-00
PublicationDecade 2010
PublicationTitle Translational and clinical pharmacology
PublicationYear 2016
Publisher 대한임상약리학회
Publisher_xml – name: 대한임상약리학회
References Barrett (10.12793/tcp.2016.24.1.13_ref39) 2005; 21
Spudich (10.12793/tcp.2016.24.1.13_ref21) 2010; 11
Landrum (10.12793/tcp.2016.24.1.13_ref23) 2014; 42
Mooney (10.12793/tcp.2016.24.1.13_ref2) 2015; 134
Abecasis (10.12793/tcp.2016.24.1.13_ref28) 2012; 491
Stephens (10.12793/tcp.2016.24.1.13_ref40) 2003; 73
Zhou (10.12793/tcp.2016.24.1.13_ref15) 2006; 44
Wang (10.12793/tcp.2016.24.1.13_ref22) 2013; 14
Roden (10.12793/tcp.2016.24.1.13_ref4) 2002; 1
Harel (10.12793/tcp.2016.24.1.13_ref25) 2009; 10
Kim (10.12793/tcp.2016.24.1.13_ref6) 2007; 9
Clark (10.12793/tcp.2016.24.1.13_ref31) 1990; 7
Excoffier (10.12793/tcp.2016.24.1.13_ref34) 1995; 12
Stephens (10.12793/tcp.2016.24.1.13_ref36) 2001; 68
Hurst (10.12793/tcp.2016.24.1.13_ref16) 2009; 2
Dalma-Weiszhausz (10.12793/tcp.2016.24.1.13_ref20) 2006; 410
Gabriel (10.12793/tcp.2016.24.1.13_ref18) 2009
Consortium (10.12793/tcp.2016.24.1.13_ref29) 2003; 426
Purcell (10.12793/tcp.2016.24.1.13_ref42) 2007; 81
Wang (10.12793/tcp.2016.24.1.13_ref1) 2011; 364
Flynn (10.12793/tcp.2016.24.1.13_ref3) 2011; 16
Stephens (10.12793/tcp.2016.24.1.13_ref41) 2005; 76
Rosenbloom (10.12793/tcp.2016.24.1.13_ref24) 2015; 43
Koch (10.12793/tcp.2016.24.1.13_ref9) 2004; 3
Consortium (10.12793/tcp.2016.24.1.13_ref30) 2005; 437
Tian (10.12793/tcp.2016.24.1.13_ref19) 2015; 35
Hsiao (10.12793/tcp.2016.24.1.13_ref12) 2012
Ronaghi (10.12793/tcp.2016.24.1.13_ref14) 2001; 11
Syrmis (10.12793/tcp.2016.24.1.13_ref17) 2013; 62
Morris (10.12793/tcp.2016.24.1.13_ref37) 2002; 70
Frederickson (10.12793/tcp.2016.24.1.13_ref11) 2002; 9
Nobile (10.12793/tcp.2016.24.1.13_ref8) 1988; 3
Barrett (10.12793/tcp.2016.24.1.13_ref32) 2009; 2009
Nikolausz (10.12793/tcp.2016.24.1.13_ref13) 2009; 37
Hawley (10.12793/tcp.2016.24.1.13_ref33) 1995; 86
Lee (10.12793/tcp.2016.24.1.13_ref5) 2010
NwanKwo (10.12793/tcp.2016.24.1.13_ref7) 2011; 5
Flicek (10.12793/tcp.2016.24.1.13_ref27) 2014; 42
Safran (10.12793/tcp.2016.24.1.13_ref26) 2010
Niu (10.12793/tcp.2016.24.1.13_ref38) 2002; 70
Livak (10.12793/tcp.2016.24.1.13_ref10) 2003; 212
Clayton (10.12793/tcp.2016.24.1.13_ref35) 1999; 65
References_xml – volume: 12
  start-page: 921
  year: 1995
  ident: 10.12793/tcp.2016.24.1.13_ref34
  publication-title: Mol Biol Evol
– volume: 5
  start-page: 148
  year: 2011
  ident: 10.12793/tcp.2016.24.1.13_ref7
  publication-title: J Pharm Res Opin
– volume: 43
  start-page: D670
  year: 2015
  ident: 10.12793/tcp.2016.24.1.13_ref24
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gku1177
– volume: 134
  start-page: 459
  year: 2015
  ident: 10.12793/tcp.2016.24.1.13_ref2
  publication-title: Hum Genet
  doi: 10.1007/s00439-014-1484-7
– volume: 7
  start-page: 111
  year: 1990
  ident: 10.12793/tcp.2016.24.1.13_ref31
  publication-title: Mol Biol Evol
– volume: 68
  start-page: 978
  year: 2001
  ident: 10.12793/tcp.2016.24.1.13_ref36
  publication-title: Am J Hum Genet
  doi: 10.1086/319501
– volume: 86
  start-page: 409
  year: 1995
  ident: 10.12793/tcp.2016.24.1.13_ref33
  publication-title: J Hered
  doi: 10.1093/oxfordjournals.jhered.a111613
– volume: 44
  start-page: 3900
  year: 2006
  ident: 10.12793/tcp.2016.24.1.13_ref15
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.01209-06
– volume: 16
  start-page: 862
  year: 2011
  ident: 10.12793/tcp.2016.24.1.13_ref3
  publication-title: Drug Discov Today
  doi: 10.1016/j.drudis.2011.08.008
– volume: 3
  start-page: 749
  year: 2004
  ident: 10.12793/tcp.2016.24.1.13_ref9
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd1496
– volume: 212
  start-page: 129
  year: 2003
  ident: 10.12793/tcp.2016.24.1.13_ref10
  publication-title: Methods Mol Biol
– volume: 11
  start-page: 3
  year: 2001
  ident: 10.12793/tcp.2016.24.1.13_ref14
  publication-title: Genome Res
  doi: 10.1101/gr.11.1.3
– volume: 70
  start-page: 157
  year: 2002
  ident: 10.12793/tcp.2016.24.1.13_ref38
  publication-title: Am J Hum Genet
  doi: 10.1086/338446
– volume-title: Curr Protoc Hum Genet
  year: 2009
  ident: 10.12793/tcp.2016.24.1.13_ref18
– volume: 14
  start-page: 131
  year: 2013
  ident: 10.12793/tcp.2016.24.1.13_ref22
  publication-title: Brief Bioinform
  doi: 10.1093/bib/bbs029
– volume: 10
  start-page: 348
  year: 2009
  ident: 10.12793/tcp.2016.24.1.13_ref25
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-10-348
– volume: 73
  start-page: 1162
  year: 2003
  ident: 10.12793/tcp.2016.24.1.13_ref40
  publication-title: Am J Hum Genet
  doi: 10.1086/379378
– volume: 1
  start-page: 37
  year: 2002
  ident: 10.12793/tcp.2016.24.1.13_ref4
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd705
– volume: 364
  start-page: 1144
  year: 2011
  ident: 10.12793/tcp.2016.24.1.13_ref1
  publication-title: N Engl J Med
  doi: 10.1056/NEJMicm1001885
– start-page: baq020
  year: 2010
  ident: 10.12793/tcp.2016.24.1.13_ref26
  publication-title: Database (Oxford)
– volume: 76
  start-page: 449
  year: 2005
  ident: 10.12793/tcp.2016.24.1.13_ref41
  publication-title: Am J Hum Genet
  doi: 10.1086/428594
– volume: 491
  start-page: 56
  year: 2012
  ident: 10.12793/tcp.2016.24.1.13_ref28
  publication-title: Nature
  doi: 10.1038/nature11632
– volume: 62
  start-page: 734
  year: 2013
  ident: 10.12793/tcp.2016.24.1.13_ref17
  publication-title: J Med Microbiol
  doi: 10.1099/jmm.0.055905-0
– volume: 410
  start-page: 3
  year: 2006
  ident: 10.12793/tcp.2016.24.1.13_ref20
  publication-title: Methods Enzymol
  doi: 10.1016/S0076-6879(06)10001-4
– volume: 3
  start-page: 272
  year: 1988
  ident: 10.12793/tcp.2016.24.1.13_ref8
  publication-title: Genomics
  doi: 10.1016/0888-7543(88)90088-2
– volume: 11
  start-page: 295
  year: 2010
  ident: 10.12793/tcp.2016.24.1.13_ref21
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-11-295
– volume: 2
  start-page: 66
  year: 2009
  ident: 10.12793/tcp.2016.24.1.13_ref16
  publication-title: BMC Res Notes
  doi: 10.1186/1756-0500-2-66
– volume: 42
  start-page: D749
  year: 2014
  ident: 10.12793/tcp.2016.24.1.13_ref27
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt1196
– start-page: 211
  volume-title: Genetic variation and Diseases (Language in Korean)
  year: 2010
  ident: 10.12793/tcp.2016.24.1.13_ref5
– start-page: 35
  volume-title: Despina Sanoudou (ed) Clinical Applications
  year: 2012
  ident: 10.12793/tcp.2016.24.1.13_ref12
– volume: 42
  start-page: D980
  year: 2014
  ident: 10.12793/tcp.2016.24.1.13_ref23
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt1113
– volume: 81
  start-page: 559
  year: 2007
  ident: 10.12793/tcp.2016.24.1.13_ref42
  publication-title: Am J Hum Genet
  doi: 10.1086/519795
– volume: 35
  start-page: 136
  year: 2015
  ident: 10.12793/tcp.2016.24.1.13_ref19
  publication-title: Mol Breed
  doi: 10.1007/s11032-015-0335-0
– volume: 70
  start-page: 686
  year: 2002
  ident: 10.12793/tcp.2016.24.1.13_ref37
  publication-title: Am J Hum Genet
  doi: 10.1086/339271
– volume: 9
  start-page: 289
  year: 2007
  ident: 10.12793/tcp.2016.24.1.13_ref6
  publication-title: Annu Rev Biomed Eng
  doi: 10.1146/annurev.bioeng.9.060906.152037
– volume: 37
  start-page: 454
  year: 2009
  ident: 10.12793/tcp.2016.24.1.13_ref13
  publication-title: Biochem Soc Trans
  doi: 10.1042/BST0370454
– volume: 21
  start-page: 263
  year: 2005
  ident: 10.12793/tcp.2016.24.1.13_ref39
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bth457
– volume: 2009
  start-page: pdb
  year: 2009
  ident: 10.12793/tcp.2016.24.1.13_ref32
  publication-title: Cold Spring Harb Protoc
  doi: 10.1101/pdb.ip71
– volume: 437
  start-page: 1299
  year: 2005
  ident: 10.12793/tcp.2016.24.1.13_ref30
  publication-title: Nature
  doi: 10.1038/nature04226
– volume: 9
  start-page: 1161
  year: 2002
  ident: 10.12793/tcp.2016.24.1.13_ref11
  publication-title: Chem Biol
  doi: 10.1016/S1074-5521(02)00266-1
– volume: 426
  start-page: 789
  year: 2003
  ident: 10.12793/tcp.2016.24.1.13_ref29
  publication-title: Nature
  doi: 10.1038/nature02168
– volume: 65
  start-page: 1170
  year: 1999
  ident: 10.12793/tcp.2016.24.1.13_ref35
  publication-title: Am J Hum Genet
  doi: 10.1086/302577
SSID ssj0001343160
Score 1.9543512
SecondaryResourceType review_article
Snippet There is increasing interest in the application of personalized therapy to healthcare to increase the effectiveness of and reduce the adverse reactions to...
SourceID nrf
crossref
SourceType Open Website
Index Database
StartPage 13
SubjectTerms 의약학
Title Brief introduction to current pharmacogenomics research tools
URI https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002091292
Volume 24
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Translational and Clinical Pharmacology, 2016, 24(1), , pp.13-21
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELa27YULKgJEeSlI-IK0IXEedo55VYUDp1bqzXKcBKGW3dU2vfBT-TWdsZ1suhSpcIksZzKJPSN7ZjLzmZCPTSvSuAPvpE0YRwclXjaYNK65wh9xiAhiEmS_pWcX8dfL5HKx-D3LWrodGl__erCu5H-kCn0gV6yS_QfJTkyhA9ogX7iChOH6KBmDZ98ZxAcL24qSBFNSO8iljUOlRhjWnwjG7IB9sH5qfX0zN0vNjnU9xgVNqdtYMbnZYVtP0Xdal7QIaC6wkVWYLYENQUU4J8kDmiW0rvBOVk60O5KcFtn4cI4cH-IiCmRkuRRi4jsPV9g6SqNatC6oKA3TCt_u3ltTERtmEXA3PQktKiTOU5qXI3FmGjlw2C2QjGG6l7CHF_md7QOPe5nEFm_ALcq22NVt77Ye-4-Ng3GDqjVoxDANU5_FfuiPD85Buvc2z3sw3Vf6h_y-lldbCc7IF4kneMfigBwxzkNYcY_yoipOdxHACGEIMAg4DcT9dseP-bz_KfcMp4PVtp_ZQefH5KlzYLzcauMzsuhWz4nVRG-uid6w9pwmevua6I2a6BlNfEEuTuvz8mzpDuZY6lDA_HKRtb2GpT4KAsWbpmM9WNU6BdM21UwIoYKWpWAYdmmkEEBSIcybUi0LVMt5G70kh6v1qntFPBhho_osYDpUcaParAeXg_GmZbFo0qA7IZ_GUcuNxV-R6LfiFEmYIolTJFksQxlGJ-QDzIsRw1_F8foRNG_IE2RrI21vyeGwve3ege05NO-dEO8AOQ5vOg
linkProvider EBSCOhost
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Brief+introduction+to+current+pharmacogenomics+research+tools&rft.jtitle=Translational+and+clinical+pharmacology&rft.au=%EC%B0%A8%EC%9D%80%EC%98%81&rft.au=%EC%A0%95%ED%98%9C%EC%9D%80&rft.au=%EA%B9%80%EC%9A%B0%EC%98%81&rft.au=%EC%8B%A0%ED%98%B8%EC%A0%95&rft.date=2016&rft.pub=%EB%8C%80%ED%95%9C%EC%9E%84%EC%83%81%EC%95%BD%EB%A6%AC%ED%95%99%ED%9A%8C&rft.issn=2289-0882&rft.eissn=2383-5427&rft.spage=13&rft.epage=21&rft_id=info:doi/10.12793%2Ftcp.2016.24.1.13&rft.externalDBID=n%2Fa&rft.externalDocID=oai_kci_go_kr_ARTI_160348
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2289-0882&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2289-0882&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2289-0882&client=summon