Tumor Microenvironment Reprogramming Improves Nanomedicine-Based Chemo-Immunotherapy in Sarcomas

• Published in: Molecular cancer therapeutics Vol. 23; no. 11; pp. 1555 - 1567
• Main Authors: Charalambous, Antonia, Mpekris, Fotios, Panagi, Myrofora, Voutouri, Chrysovalantis, Michael, Christina, Gabizon, Alberto A, Stylianopoulos, Triantafyllos
• Format: Journal Article
• Language: English
• Published: United States 04.11.2024
• Subjects: Animals; Cell Line, Tumor; Doxorubicin - administration & dosage; Doxorubicin - analogs & derivatives; Doxorubicin - pharmacology; Doxorubicin - therapeutic use; Female; Humans; Immunotherapy - methods; Mice; Nanomedicine - methods; Polyethylene Glycols - chemistry; Sarcoma - drug therapy; Sarcoma - pathology; Sarcoma - therapy; Tumor Microenvironment - drug effects

Sarcomas are a heterogeneous group of rare cancers that originate in soft tissues or bones. Their complexity and tendency for metastases make treatment challenging, highlighting the need for new therapeutic approaches to improve patient survival. The difficulties in treating these cancers primarily...