The role of reactive oxygen species in the regulation of the blood-brain barrier

The blood-brain barrier (BBB) regulates the exchange of metabolites and cells between the blood and brain, and maintains central nervous system homeostasis. Various factors affect BBB barrier functions, including reactive oxygen species (ROS). ROS can act as stressors, damaging biological molecules,...

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Published inTissue barriers p. 2361202
Main Authors Shuvalova, Margarita, Dmitrieva, Anastasiia, Belousov, Vsevolod, Nosov, Georgii
Format Journal Article
LanguageEnglish
Published United States 29.05.2024
Subjects
redox signaling
BBB
multiple sclerosis
ROS
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Abstract The blood-brain barrier (BBB) regulates the exchange of metabolites and cells between the blood and brain, and maintains central nervous system homeostasis. Various factors affect BBB barrier functions, including reactive oxygen species (ROS). ROS can act as stressors, damaging biological molecules, but they also serve as secondary messengers in intracellular signaling cascades during redox signaling. The impact of ROS on the BBB has been observed in multiple sclerosis, stroke, trauma, and other neurological disorders, making blocking ROS generation a promising therapeutic strategy for BBB dysfunction. However, it is important to consider ROS generation during normal BBB functioning for signaling purposes. This review summarizes data on proteins expressed by BBB cells that can be targets of redox signaling or oxidative stress. It also provides examples of signaling molecules whose impact may cause ROS generation in the BBB, as well as discusses the most common diseases associated with BBB dysfunction and excessive ROS generation, open questions that arise in the study of this problem, and possible ways to overcome them.
AbstractList The blood-brain barrier (BBB) regulates the exchange of metabolites and cells between the blood and brain, and maintains central nervous system homeostasis. Various factors affect BBB barrier functions, including reactive oxygen species (ROS). ROS can act as stressors, damaging biological molecules, but they also serve as secondary messengers in intracellular signaling cascades during redox signaling. The impact of ROS on the BBB has been observed in multiple sclerosis, stroke, trauma, and other neurological disorders, making blocking ROS generation a promising therapeutic strategy for BBB dysfunction. However, it is important to consider ROS generation during normal BBB functioning for signaling purposes. This review summarizes data on proteins expressed by BBB cells that can be targets of redox signaling or oxidative stress. It also provides examples of signaling molecules whose impact may cause ROS generation in the BBB, as well as discusses the most common diseases associated with BBB dysfunction and excessive ROS generation, open questions that arise in the study of this problem, and possible ways to overcome them.
Author Shuvalova, Margarita
Dmitrieva, Anastasiia
Nosov, Georgii
Belousov, Vsevolod
Author_xml – sequence: 1
  givenname: Margarita
  surname: Shuvalova
  fullname: Shuvalova, Margarita
  organization: Department of metabolism and redox biology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
– sequence: 2
  givenname: Anastasiia
  surname: Dmitrieva
  fullname: Dmitrieva, Anastasiia
  organization: Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia
– sequence: 3
  givenname: Vsevolod
  surname: Belousov
  fullname: Belousov, Vsevolod
  organization: Life Improvement by Future Technologies (LIFT) Center, Skolkovo, Moscow, Russia
– sequence: 4
  givenname: Georgii
  surname: Nosov
  fullname: Nosov, Georgii
  organization: Life Improvement by Future Technologies (LIFT) Center, Skolkovo, Moscow, Russia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38808582$$D View this record in MEDLINE/PubMed
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multiple sclerosis
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– ident: e_1_3_2_42_1
  doi: 10.1083/jcb.127.6.1617
– ident: e_1_3_2_71_1
  doi: 10.1093/jnen/62.6.593
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Snippet The blood-brain barrier (BBB) regulates the exchange of metabolites and cells between the blood and brain, and maintains central nervous system homeostasis....
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Title The role of reactive oxygen species in the regulation of the blood-brain barrier
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