Polymyxin B adjuvants against polymyxin B- and carbapenem-resistant Gram-negative bacteria

• Published in: Future microbiology p. 1
• Main Authors: Salvaterra Pasquini, João Paulo, Queiroz, Paula Assis, Rodrigues do Amaral, Pedro Henrique, da Silva, Thalita Camilo, Souza Bonfim Mendonça, Patricia de, Vandresen, Fábio, Carvalho Ceolis, João Pedro, de Lima Scodro, Regiane Bertin, Caleffi-Ferracioli, Katiany Rizzieri, Cardoso, Rosilene Fressatti, Dias Siqueira, Vera Lúcia
• Format: Journal Article
• Language: English
• Published: England 11.09.2024
• Subjects: isoniazid-acylhydrazones derivatives; 3,5-dinitrobenzoylhydrazonic derivatives; polymyxin; bacterial resistance; enterobacterales

Polymyxin B (PMB) is one of the few therapeutic options for treating infections caused by carbapenem-resistant Gram-negative bacteria (CR-GNB). However, the emergence of PMB-resistant CR-GNB strains has prompted the exploration of antibiotic adjuvants as potential therapeutic avenues. Thus, this stu...