E-Cadherin Induces Serine Synthesis to Support Progression and Metastasis of Breast Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 84; no. 17; pp. 2820 - 2835
• Main Authors: Lee, Geonhui, Wong, Claudia, Cho, Anna, West, Junior J, Crawford, Ashleigh J, Russo, Gabriella C, Si, Bishwa R, Kim, Jungwoo, Hoffner, Lauren, Jang, Cholsoon, Jung, Moonjung, Leone, Robert D, Konstantopoulos, Konstantinos, Ewald, Andrew J, Wirtz, Denis, Jeong, Sangmoo
• Format: Journal Article
• Language: English
• Published: United States 04.09.2024
• Subjects: Animals; Antigens, CD - metabolism; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cadherins - metabolism; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Epithelial-Mesenchymal Transition; Female; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Oxidative Stress; Phosphoglycerate Dehydrogenase - genetics; Phosphoglycerate Dehydrogenase - metabolism; Serine - metabolism

The loss of E-cadherin, an epithelial cell adhesion molecule, has been implicated in metastasis by mediating the epithelial-mesenchymal transition, which promotes invasion and migration of cancer cells. However, recent studies have demonstrated that E-cadherin supports the survival and proliferation...