Genome-Led Discovery of the Antibacterial Cyclic Lipopeptide Kutzneridine A and Its Silent Biosynthetic Gene Cluster from Kutzneria Species

• Published in: Journal of natural products (Washington, D.C.)
• Main Authors: Ortiz-López, Francisco Javier, Oves-Costales, Daniel, Guerrero Garzón, Jaime Felipe, Gren, Tetiana, Baggesgaard Sterndorff, Eva, Jiang, Xinglin, Sparholt Jo Rgensen, Tue, Blin, Kai, Fernández-Pastor, Ignacio, Tormo, José R, Martín, Jesús, Sánchez, Pilar, Moreno, Mercedes de la Cruz, Reyes, Fernando, Genilloud, Olga, Weber, Tilmann
• Format: Journal Article
• Language: English
• Published: United States 27.09.2024

Genome analysis of sp. CA-103260 revealed a putative lipopeptide-encoding biosynthetic gene cluster (BGC) that was cloned into a bacterial artificial chromosome (BAC) and heterologously expressed in M1152. As a result, a novel cyclic lipo-tetrapeptide containing two diaminopropionic acid residues an...