Genome-Led Discovery of the Antibacterial Cyclic Lipopeptide Kutzneridine A and Its Silent Biosynthetic Gene Cluster from Kutzneria Species

Genome analysis of sp. CA-103260 revealed a putative lipopeptide-encoding biosynthetic gene cluster (BGC) that was cloned into a bacterial artificial chromosome (BAC) and heterologously expressed in M1152. As a result, a novel cyclic lipo-tetrapeptide containing two diaminopropionic acid residues an...

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Published inJournal of natural products (Washington, D.C.)
Main Authors Ortiz-López, Francisco Javier, Oves-Costales, Daniel, Guerrero Garzón, Jaime Felipe, Gren, Tetiana, Baggesgaard Sterndorff, Eva, Jiang, Xinglin, Sparholt Jo Rgensen, Tue, Blin, Kai, Fernández-Pastor, Ignacio, Tormo, José R, Martín, Jesús, Sánchez, Pilar, Moreno, Mercedes de la Cruz, Reyes, Fernando, Genilloud, Olga, Weber, Tilmann
Format Journal Article
LanguageEnglish
Published United States 27.09.2024
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Abstract Genome analysis of sp. CA-103260 revealed a putative lipopeptide-encoding biosynthetic gene cluster (BGC) that was cloned into a bacterial artificial chromosome (BAC) and heterologously expressed in M1152. As a result, a novel cyclic lipo-tetrapeptide containing two diaminopropionic acid residues and an exotic , -acetonide ring, kutzneridine A ( ), was isolated and structurally characterized. Evaluation of the extraction conditions and isotope-labeling chemical modifications showed that the acetonide ring originated from acetone during isolation. The BGC was analyzed and a biosynthetic pathway to was proposed. Kutzneridine A displayed remarkable antibacterial activity against methicillin-resistant and vancomycin-resistant .
AbstractList Genome analysis of sp. CA-103260 revealed a putative lipopeptide-encoding biosynthetic gene cluster (BGC) that was cloned into a bacterial artificial chromosome (BAC) and heterologously expressed in M1152. As a result, a novel cyclic lipo-tetrapeptide containing two diaminopropionic acid residues and an exotic , -acetonide ring, kutzneridine A ( ), was isolated and structurally characterized. Evaluation of the extraction conditions and isotope-labeling chemical modifications showed that the acetonide ring originated from acetone during isolation. The BGC was analyzed and a biosynthetic pathway to was proposed. Kutzneridine A displayed remarkable antibacterial activity against methicillin-resistant and vancomycin-resistant .
Genome analysis of Kutzneria sp. CA-103260 revealed a putative lipopeptide-encoding biosynthetic gene cluster (BGC) that was cloned into a bacterial artificial chromosome (BAC) and heterologously expressed in Streptomyces coelicolor M1152. As a result, a novel cyclic lipo-tetrapeptide containing two diaminopropionic acid residues and an exotic N,N-acetonide ring, kutzneridine A (1), was isolated and structurally characterized. Evaluation of the extraction conditions and isotope-labeling chemical modifications showed that the acetonide ring originated from acetone during isolation. The BGC was analyzed in silico and a biosynthetic pathway to 1 was proposed. Kutzneridine A displayed remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.Genome analysis of Kutzneria sp. CA-103260 revealed a putative lipopeptide-encoding biosynthetic gene cluster (BGC) that was cloned into a bacterial artificial chromosome (BAC) and heterologously expressed in Streptomyces coelicolor M1152. As a result, a novel cyclic lipo-tetrapeptide containing two diaminopropionic acid residues and an exotic N,N-acetonide ring, kutzneridine A (1), was isolated and structurally characterized. Evaluation of the extraction conditions and isotope-labeling chemical modifications showed that the acetonide ring originated from acetone during isolation. The BGC was analyzed in silico and a biosynthetic pathway to 1 was proposed. Kutzneridine A displayed remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.
Author Sparholt Jo Rgensen, Tue
Martín, Jesús
Ortiz-López, Francisco Javier
Baggesgaard Sterndorff, Eva
Jiang, Xinglin
Genilloud, Olga
Moreno, Mercedes de la Cruz
Weber, Tilmann
Blin, Kai
Sánchez, Pilar
Guerrero Garzón, Jaime Felipe
Tormo, José R
Reyes, Fernando
Gren, Tetiana
Oves-Costales, Daniel
Fernández-Pastor, Ignacio
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Snippet Genome analysis of sp. CA-103260 revealed a putative lipopeptide-encoding biosynthetic gene cluster (BGC) that was cloned into a bacterial artificial...
Genome analysis of Kutzneria sp. CA-103260 revealed a putative lipopeptide-encoding biosynthetic gene cluster (BGC) that was cloned into a bacterial artificial...
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Title Genome-Led Discovery of the Antibacterial Cyclic Lipopeptide Kutzneridine A and Its Silent Biosynthetic Gene Cluster from Kutzneria Species
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