Predictive factors and treatment outcomes associated with difficult-to-treat rheumatoid arthritis conditions: the ANSWER cohort study

• Published in: Rheumatology (Oxford, England) Vol. 63; no. 9; pp. 2418 - 2426
• Main Authors: Watanabe, Ryu, Ebina, Kosuke, Gon, Takaho, Okano, Tadashi, Murata, Koichi, Murakami, Kosaku, Maeda, Yuichi, Jinno, Sadao, Shirasugi, Iku, Son, Yonsu, Amuro, Hideki, Katayama, Masaki, Hara, Ryota, Hata, Kenichiro, Yoshikawa, Ayaka, Yamamoto, Wataru, Tachibana, Shotaro, Hayashi, Shinya, Etani, Yuki, Katsushima, Masao, Fukumoto, Kazuo, Yamada, Shinsuke, Hashimoto, Motomu
• Format: Journal Article
• Language: English
• Published: England 01.09.2024
• Subjects: Age Factors; Aged; Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - drug therapy; Biological Products - therapeutic use; Cohort Studies; Female; Humans; Janus Kinase Inhibitors - therapeutic use; Japan - epidemiology; Male; Methotrexate - therapeutic use; Middle Aged; Proportional Hazards Models; Retrospective Studies; Rheumatoid Factor - blood; Severity of Illness Index; Treatment Outcome; Japan; tumour necrosis factor inhibitors; difficult-to-treat rheumatoid arthritis; anti-interleukin-6 receptor antibodies; Janus kinase inhibitors

To investigate the predictive factors for difficult-to-treat rheumatoid arthritis (D2T RA) and assess the efficacy of biologic DMARDs (bDMARDs) and Janus kinase inhibitors (JAKi). Retrospective analysis was conducted on data from the ANSWER cohort comprising 3623 RA patients treated with bDMARDs or...