Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome

• Published in: Blood
• Main Authors: Breillat, Paul, Carbone, Francesco, Lereclus, Emilie, Riller, Quentin, d'Izarny-Gargas, Thibaut, Possémé, Céline, Templé, Marie, Zhao, Lin-Pierre, Luka, Marine, Lazaro, Estibaliz, Outh, Rodereau, Le Guenno, Guillaume, Lifermann, François, Dieudonné, Yannick, Berleur, Marie, Lenormand, Cédric, Balabanian, Karl, Weitten, Thierry, Guillotin, Vivien, Kostine, Marie, Burroni, Barbara, Bigot, Adrien, Audemard-Verger, Alexandra, Manuel, Aldric, Dossier, Antoine, Golden, Cécile, Martellosio, Jean-Philippe, Faucher, Benoit, De Sainte Marie, Benjamin, Magy-Bertrand, Nadine, Lacombe, Valentin, Vinzio, Stéphane, Grosleron, Sylvie, Dionet, Léa, Tharaux, Pierre-Louis, Duffy, Darragh, Ménager, Mickael, Dulphy, Nicolas, Kosmider, Olivier, Terrier, Benjamin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.07.2025; American Society of Hematology
• Subjects: Life Sciences; NK cells; severe infections; UBA1; VEXAS syndrome; severe infections; VEXAS syndrome; NK cells; UBA1

-NK cell phenotyping reveals impaired cytotoxicity, chronic activation, and exhaustion in VEXAS syndrome.-Decreased circulating NK cells were independently associated with an increased risk of severe infections in VEXAS syndrome. VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndr...