The Role of the Gene–Gene and Gene–Environment Interactions of Polymorphic Loci of Matrix Metalloproteinases in Forming the Risk of Ischemic Stroke on the Background of Arterial Hypertension in Men
Objectives. To analyze the role of genetic polymorphisms of matrix metalloproteinase ( MMP ) genes and their gene–gene and gene–environment interactions in the formation of ischemic stroke (IS) in men with arterial hypertension (AH). Materials and methods. The study included 523 men with hypertensio...
Saved in:
Published in | Neuroscience and behavioral physiology Vol. 53; no. 4; pp. 496 - 502 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Cham
Springer International Publishing
01.05.2023
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Objectives.
To analyze the role of genetic polymorphisms of matrix metalloproteinase (
MMP
) genes and their gene–gene and gene–environment interactions in the formation of ischemic stroke (IS) in men with arterial hypertension (AH).
Materials and methods.
The study included 523 men with hypertension: 201 with IS and 322 without stroke. The relationship between
MMP
loci and the formation of stroke in the presence of hypertension was determined by logistic regression analysis in dominant, recessive, and additive genetic models using PLINK v.2.050 software. Haplotype analysis was performed for five single nucleotide polymorphisms (SNP) co-located on chromosome 11 (314.3 kb), and associations of haplotypes with the development of stroke were identified using the EM algorithm. Gene–gene and gene–environment interactions between
MMP
and smoking and alcohol consumption in the development of stroke were assessed by the generalized multifactor dimensionality reduction (GMDR) method using GMDR v.0.9 software.
Results.
The rs3025058 polymorphic locus was found to be associated with IS in men in the dominant and additive genetic models (OR = 0.63–0.74,
p
perm
= 0.03). Four
MMP
haplotypes had protective effects in relation to the development of stroke in the presence of hypertension (OR = 0.48–0.50,
p
perm
= 0.02–0.03). Four models of gene–gene interactions of
MMP
polymorphic loci (OR = 2.19–2.55,
p
perm
< 0.001) and three four-way models of gene–environment interactions of
MMP
with alcohol abuse (OR = 2.82–3.11,
p
perm
< 0.001 ) were associated with high risks of developing IS in men with hypertension. rs3025058, rs1320632, rs11225395, and rs1799750 demonstrated the largest contributions to gene–gene and gene–environment interactions on formation of IS.
Conclusions.
The results obtained here indicate that the interactions of
MMP
genes with each other and with modifiable environmental factors play a significant role in the development of stroke on the background of AH in men. |
---|---|
AbstractList | Objectives.
To analyze the role of genetic polymorphisms of matrix metalloproteinase (
MMP
) genes and their gene–gene and gene–environment interactions in the formation of ischemic stroke (IS) in men with arterial hypertension (AH).
Materials and methods.
The study included 523 men with hypertension: 201 with IS and 322 without stroke. The relationship between
MMP
loci and the formation of stroke in the presence of hypertension was determined by logistic regression analysis in dominant, recessive, and additive genetic models using PLINK v.2.050 software. Haplotype analysis was performed for five single nucleotide polymorphisms (SNP) co-located on chromosome 11 (314.3 kb), and associations of haplotypes with the development of stroke were identified using the EM algorithm. Gene–gene and gene–environment interactions between
MMP
and smoking and alcohol consumption in the development of stroke were assessed by the generalized multifactor dimensionality reduction (GMDR) method using GMDR v.0.9 software.
Results.
The rs3025058 polymorphic locus was found to be associated with IS in men in the dominant and additive genetic models (OR = 0.63–0.74,
p
perm
= 0.03). Four
MMP
haplotypes had protective effects in relation to the development of stroke in the presence of hypertension (OR = 0.48–0.50,
p
perm
= 0.02–0.03). Four models of gene–gene interactions of
MMP
polymorphic loci (OR = 2.19–2.55,
p
perm
< 0.001) and three four-way models of gene–environment interactions of
MMP
with alcohol abuse (OR = 2.82–3.11,
p
perm
< 0.001 ) were associated with high risks of developing IS in men with hypertension. rs3025058, rs1320632, rs11225395, and rs1799750 demonstrated the largest contributions to gene–gene and gene–environment interactions on formation of IS.
Conclusions.
The results obtained here indicate that the interactions of
MMP
genes with each other and with modifiable environmental factors play a significant role in the development of stroke on the background of AH in men. Objectives. To analyze the role of genetic polymorphisms of matrix metalloproteinase (MMP) genes and their gene–gene and gene–environment interactions in the formation of ischemic stroke (IS) in men with arterial hypertension (AH). Materials and methods. The study included 523 men with hypertension: 201 with IS and 322 without stroke. The relationship between MMP loci and the formation of stroke in the presence of hypertension was determined by logistic regression analysis in dominant, recessive, and additive genetic models using PLINK v.2.050 software. Haplotype analysis was performed for five single nucleotide polymorphisms (SNP) co-located on chromosome 11 (314.3 kb), and associations of haplotypes with the development of stroke were identified using the EM algorithm. Gene–gene and gene–environment interactions between MMP and smoking and alcohol consumption in the development of stroke were assessed by the generalized multifactor dimensionality reduction (GMDR) method using GMDR v.0.9 software. Results. The rs3025058 polymorphic locus was found to be associated with IS in men in the dominant and additive genetic models (OR = 0.63–0.74, pperm = 0.03). Four MMP haplotypes had protective effects in relation to the development of stroke in the presence of hypertension (OR = 0.48–0.50, pperm = 0.02–0.03). Four models of gene–gene interactions of MMP polymorphic loci (OR = 2.19–2.55, pperm < 0.001) and three four-way models of gene–environment interactions of MMP with alcohol abuse (OR = 2.82–3.11, pperm < 0.001 ) were associated with high risks of developing IS in men with hypertension. rs3025058, rs1320632, rs11225395, and rs1799750 demonstrated the largest contributions to gene–gene and gene–environment interactions on formation of IS. Conclusions. The results obtained here indicate that the interactions of MMP genes with each other and with modifiable environmental factors play a significant role in the development of stroke on the background of AH in men. |
Author | Churnosov, M. I. Efremova, O. A. Batlutskaya, I. V. Kalinina, M. I. Ponomarenko, I. V. |
Author_xml | – sequence: 1 givenname: M. I. surname: Kalinina fullname: Kalinina, M. I. email: mariam31011989@yandex.ru organization: Belgorod State National Research University – sequence: 2 givenname: I. V. surname: Ponomarenko fullname: Ponomarenko, I. V. organization: Belgorod State National Research University – sequence: 3 givenname: O. A. surname: Efremova fullname: Efremova, O. A. organization: Belgorod State National Research University – sequence: 4 givenname: I. V. surname: Batlutskaya fullname: Batlutskaya, I. V. organization: Belgorod State National Research University – sequence: 5 givenname: M. I. surname: Churnosov fullname: Churnosov, M. I. organization: Belgorod State National Research University |
BookMark | eNp9UctuGyEURVUq1Un7A10hZT0JDGBmlmmUhyVbjfKQskMY37GJZ8ABHMVe9R_6Vf2NfkkZO1F32XAvcM655-ocogPnHSD0nZITSog8jZQSIQpSsoJQzmWx_YQGVEhWVHX9eIAGhNSyIILXX9BhjE8kk2RFBujP_QLwrW8B-wan3F-Bg7-_fvcFazd7v1-4Fxu868AlPHIJgjbJehd72o1vN50Pq4U1eOyN7d8mOgX7iieQdNv6VfAJrNMRIrYOX_rQWTffzbu1cdkTRtEsoMsKdyn4Zbbjdt8_tFnOg19nJxl0FvJkq1t8vVlB7l3MHnrFCbiv6HOj2wjf3uoReri8uD-_LsY_r0bnZ-PC0EpsCyOmkpq8PtRiyuVQgpgZ0TRmSqeMMGhI02iqYcZpLTWrWT4qzmlZVpUZzoAdoeO9bl7qeQ0xqSe_Di6PVGXFBeNkyGVGlXuUCT7GAI1aBdvpsFGUqD4ytY9M5cjULjK1zSS2J8UMdnMI_6U_YP0DyBihuw |
Cites_doi | 10.1016/j.atherosclerosis.2009.09.019 10.1038/s41440-018-0142-1 10.1002/glia.20596 10.1212/WNL.0000000000004325 10.1097/HJH.0000000000000699 10.17116/jnevro201911903211 10.1007/s00018-019-03175-5 10.1016/j.jns.2014.04.036 10.1038/s41598-021-84645-4 10.18413/2313-8955-2018-4-1-53-69 10.4238/2015.December.30.3 10.1161/STROKEAHA.110.593798 10.3390/jcm8112011 10.1016/j.nbd.2010.03.008 10.18705/1607-419X-2020-26-5-518-525 10.2147/NDT.S152256 10.1177/0271678X17695572 10.1016/j.jacc.2013.10.032 10.1001/jama.289.5.579 10.1159/000441103 10.1161/01.str.0000031929.05665.da 10.1001/jama.289.19.2560 10.1161/01.str.21.4.637 10.18413/2658-6533-2020-7-1-0-2 10.1016/j.jstrokecerebrovasdis.2017.08.021 10.1111/jnc.13415 10.1161/01.cir.0000441139.02102.80 10.1016/j.nucmedbio.2014.04.085 10.1016/bs.pmbts.2017.04.003 10.1523/JNEUROSCI.3467-10.2010 10.15829/1728-8800-2021-3087 10.1002/jcb.28815 |
ContentType | Journal Article |
Copyright | Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
Copyright_xml | – notice: Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
DBID | AAYXX CITATION 3V. 7QG 7QR 7TK 7TS 7X7 7XB 88E 88G 8AO 8FD 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ K9. M0S M1P M2M P64 PQEST PQQKQ PQUKI PRINS PSYQQ Q9U |
DOI | 10.1007/s11055-023-01447-z |
DatabaseName | CrossRef ProQuest Central (Corporate) Animal Behavior Abstracts Chemoreception Abstracts Neurosciences Abstracts Physical Education Index Proquest Health & Medical Complete ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) ProQuest Pharma Collection Technology Research Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials AUTh Library subscriptions: ProQuest Central ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Psychology Database (ProQuest) Biotechnology and BioEngineering Abstracts ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic |
DatabaseTitle | CrossRef ProQuest One Psychology ProQuest Central Student Technology Research Database ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Pharma Collection ProQuest Central China Physical Education Index ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Chemoreception Abstracts ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition Animal Behavior Abstracts Engineering Research Database ProQuest One Academic ProQuest Central (Alumni) |
DatabaseTitleList | ProQuest One Psychology |
Database_xml | – sequence: 1 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology |
EISSN | 1573-899X |
EndPage | 502 |
ExternalDocumentID | 10_1007_s11055_023_01447_z |
GroupedDBID | --- -4W -56 -5G -BR -EM -Y2 -~C .86 .GJ .VR 06C 06D 0R~ 0VY 1N0 1SB 2.D 28- 29N 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 3SX 3V. 4.4 406 408 409 40D 40E 53G 5QI 5RE 5VS 642 67N 67Z 6NX 78A 7X7 88E 8AO 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AABYN AAFGU AAHNG AAIAL AAJKR AANXM AANZL AAPBV AARHV AARTL AATNV AATVU AAUYE AAWCG AAYFA AAYIU AAYQN AAYTO ABBBX ABBXA ABDZT ABECU ABELW ABFGW ABFTV ABHLI ABHQN ABIVO ABJNI ABJOX ABKAS ABKCH ABKTR ABMNI ABMQK ABNWP ABQBU ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACBMV ACBRV ACBYP ACGFS ACHSB ACHXU ACIGE ACIPQ ACIWK ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACSNA ACTTH ACVWB ACWMK ADBBV ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADMDM ADOAH ADOXG ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEEQQ AEFIE AEFTE AEGAL AEGNC AEJHL AEJRE AEKMD AEOHA AEPYU AESKC AESTI AETLH AEVLU AEVTX AEXYK AFEXP AFGCZ AFKRA AFLOW AFNRJ AFQWF AFRAH AFWTZ AFZKB AGAYW AGDGC AGGBP AGGDS AGJBK AGMZJ AGQMX AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIIXL AILAN AIMYW AITGF AJBLW AJDOV AJRNO AKQUC ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG AOSHJ ARMRJ ASPBG AVWKF AXYYD AZFZN AZQEC B-. BA0 BBWZM BDATZ BENPR BGNMA BPHCQ BVXVI CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 DWQXO EBLON EBS EIOEI EJD EMB EMOBN EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ6 GQ7 GQ8 GXS HF~ HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ IHE IJ- IKXTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C JBSCW JCJTX JZLTJ KDC KOV KOW KPH L7B LAK LLZTM M1P M2M M4Y MA- N2Q N9A NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 P2P PF0 PQQKQ PROAC PSQYO PSYQQ PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI RNS ROL RPX RRX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW STPWE SV3 SZN T13 T16 TEORI TSG TSK TSV TUC U2A U9L UG4 UKHRP UNUBA UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK6 WK8 XOL XU3 YLTOR YQT ZGI ZMTXR ZOVNA ZXP ~EX AACDK AAEOY AAJBT AAQLM AASML AAYXX ABAKF ACAOD ACDTI ACZOJ AEFQL AEMSY AFBBN AGQEE AGRTI AIGIU ALIPV CITATION H13 7QG 7QR 7TK 7TS 7XB 8FD 8FK FR3 K9. P64 PQEST PQUKI PRINS Q9U |
ID | FETCH-LOGICAL-c185z-c5b71c007e95b4767e5dc5ffcb1b303ef0ffa1aed4197a3937a384412288c6de3 |
IEDL.DBID | U2A |
ISSN | 0097-0549 |
IngestDate | Wed Sep 25 02:25:29 EDT 2024 Thu Sep 12 18:26:54 EDT 2024 Sat Dec 16 12:03:54 EST 2023 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Keywords | matrix metalloproteinases ischemic stroke gene–environment interactions |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c185z-c5b71c007e95b4767e5dc5ffcb1b303ef0ffa1aed4197a3937a384412288c6de3 |
PQID | 2845340647 |
PQPubID | 38002 |
PageCount | 7 |
ParticipantIDs | proquest_journals_2845340647 crossref_primary_10_1007_s11055_023_01447_z springer_journals_10_1007_s11055_023_01447_z |
PublicationCentury | 2000 |
PublicationDate | 2023-05-01 |
PublicationDateYYYYMMDD | 2023-05-01 |
PublicationDate_xml | – month: 05 year: 2023 text: 2023-05-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | Cham |
PublicationPlace_xml | – name: Cham – name: New York |
PublicationTitle | Neuroscience and behavioral physiology |
PublicationTitleAbbrev | Neurosci Behav Physi |
PublicationYear | 2023 |
Publisher | Springer International Publishing Springer Nature B.V |
Publisher_xml | – name: Springer International Publishing – name: Springer Nature B.V |
References | Barker-ColloSBennettDAKrishnamurthiRVSex differences in stroke incidence, prevalence, mortality and disability-adjusted life years: results from the Global Burden of Disease Study 2013Neuroepidemiology201545320321410.1159/00044110326505984 MontanerJRamiroLSimatsAMatrix metalloproteinases and ADAMs in strokeCell. Mol. Life Sci.20197616311731401:CAS:528:DC%2BC1MXhtFWqtbbP10.1007/s00018-019-03175-531165904 OsipovaOAGostevaEVBelousovaONDynamics of markers of fibrosis and dysfunctions of the endothelium of the vascular wall during the use of beta-blockers in elderly patients with hypertension after ischemic strokeKardiovask. Ter. Profilakt.2021208308710.15829/1728-8800-2021-3087 PolonikovAVUshachevDVIvanovVPAltered erythrocyte membrane protein composition mirrors pleiotropic effects of hypertension susceptibility genes and disease pathogenesisJ. Hypertens.20153311226522771:CAS:528:DC%2BC2MXhsFyitrjN10.1097/HJH.000000000000069926335431 GoASMozaffarianDRogerVLHeart disease and stroke statistics – 2014 update: a report from the American Heart AssociationCirculation2014129e28e29210.1161/01.cir.0000441139.02102.8024352519 JinRYangGLiGMolecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activatorNeurobiol. Dis.2010383763851:CAS:528:DC%2BC3cXlsFagu7c%3D10.1016/j.nbd.2010.03.008203029402862862 “Special report from the National Institute of Neurological Disorders and Stroke. Classifi cation of cerebrovascular diseases III,” Stroke, 21, No. 4, 637–676 (1990), https://doi.org/10.1161/01.str.21.4.637. LiuJKhalilRAMatrix metalloproteinase inhibitors as investigational and therapeutic tools in unrestrained tissue remodeling and pathological disordersProg. Mol. Biol. Transl. Sci.20171483554201:CAS:528:DC%2BB3cXhsFWqsLvP10.1016/bs.pmbts.2017.04.003286628285548434 MüllerAKrämerSDMelettaRGene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerabilityNucl. Med. Biol.20144175625691:CAS:528:DC%2BC2cXotlyjs7s%3D10.1016/j.nucmedbio.2014.04.08524853402 ShervaRFordCEEckfeldtJHPharmacogenetic effect of the stromelysin (MMP3) polymorphism on stroke risk in relation to antihypertensive treatment: The GenHAT StudyStroke201142234381:CAS:528:DC%2BC3MXhtFCjtrY%3D10.1161/STROKEAHA.110.593798 MoskalenkoMIInvolvement of matrix metalloproteinase genes in the development of arterial hypertension and its complications (review). Research ResultsMed. Farmatsiya201841536910.18413/2313-8955-2018-4-1-53-69 ZhangQWAssociation of the matrix metalloproteinase-3 polymorphisms rs679620 and rs3025058 with ischemic stroke risk: a meta-analysisNeuropsychiatr. Dis. Treat.2018144194271:CAS:528:DC%2BC1MXnsVWltrw%3D10.2147/NDT.S152256294409035798548 BritovANPozdnyakovYMCardiovascular prevention. National recommendation of the All-Russian Scientific Cardiology SocietyKardiovask. Ter. Profilakt.201110657 ZhaoJHXuYMXingHXAssociations between matrix metalloproteinase gene polymorphisms and the development of cerebral infarctionGenet. Mol. Res.201614419418194241:CAS:528:DC%2BC28XosFCnsr4%3D10.4238/2015.December.30.326782596 VafadariBSalamianAKaczmarekLMMP-9 in translation: from molecule to brain physiology, pathology, and therapyJ. Neurochem.2016139Suppl. 2911141:CAS:528:DC%2BC28XksVOitrw%3D10.1111/jnc.1341526525923 RiveraSKhrestchatiskyMKaczmarekLMetzincin proteases and their inhibitors: foes or friends in nervous system physiology?J. Neurosci.2010304615337153571:CAS:528:DC%2BC3cXhsFWitbzN10.1523/JNEUROSCI.3467-10.2010210845913072038 PolonikovARymarovaLKlyosovaEMatrix metalloproteinases as target genes for gene regulatory networks driving molecular and cellular pathways related to a multistep pathogenesis of cerebrovascular diseaseJ. Cell. Biochem.201912016467164821:CAS:528:DC%2BC1MXosl2lsrc%3D10.1002/jcb.2881531056794 ChehaibiKHriraMYNouiraSMatrix metalloproteinase-1 and matrix metalloproteinase-12 gene polymorphisms and the risk of ischemic stroke in a Tunisian populationJ. Neurol. Sci.20143421071131:CAS:528:DC%2BC2cXosVaisbg%3D10.1016/j.jns.2014.04.03624834994 HoeperMMBogaardHJCondliffeRDefinitions and diagnosis of pulmonary hypertensionJ. Am. Coll. Cardiol.20136225425010.1016/j.jacc.2013.10.032 ZhangGLiWGuoYMMP gene polymorphisms, MMP-1-1607 1G/2G, -519 A/G, and MMP-12-82 A/G, and ischemic stroke: A meta-analysisJ. Stroke Cerebrovasc. Dis.201827114015210.1016/j.jstrokecerebrovasdis.2017.08.02128958661 F. I. Hsieh, H. Y. Chiou, C. J. Hu, et al., “Combined effects of MMP-7, MMP-8 and MMP-26 on the risk of ischemic stroke,” J. Clin. Med., 8, No. 11, 2011 (2019), https://doi.org/10.3390/jcm8112011. CleeSMA role for MMP-3 genetic variation in atherosclerosis susceptibility?Atherosclerosis201020830311:CAS:528:DC%2BC3cXkt1Chtw%3D%3D10.1016/j.atherosclerosis.2009.09.01919815209 M. I. Moskalenko, I. V. Ponomarenko, A. V. Polonikov, et al., “ The role of the stress factor in the realization of genetic predisposition to the development of stroke on the background of essential hypertension,” Zh. Nevrol. Psikhiatr., M. I. 119, No. 3, Iss. 2, 11–17 (2019), https://doi.org/10.17116/jnevro201911903211. ReynoldsKLewisBNolenJDAlcohol consumption and risk of stroke: a meta-analysisJAMA2003289557958810.1001/jama.289.5.57912578491 ChobanianAVBakrisGLBlackHRThe Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 reportJAMA2003289256025721:CAS:528:DC%2BD3sXjvFCqtrk%3D10.1001/jama.289.19.256012748199 PolonikovAVKlesovaEYAzarovaYEBioinformatic tools and Internet resources for assessing the regulatory potential of polymorphic loci identified by genome-wide association studies of multifactorial diseases (review)Nauchn. Rezult. Biomed. Issled.202171153110.18413/2658-6533-2020-7-1-0-2 HaorahJSchallKRamirezSHActivation of protein tyrosine kinases and matrix metalloproteinases causes blood–brain barrier injury: Novel mechanism for neurodegeneration associated with alcohol abuseGlia2008561788810.1002/glia.20596179439533391971 MoskalenkoMPonomarenkoIReshetnikovEPolymorphisms of the matrix metalloproteinase genes are associated with essential hypertension in a Caucasian population of Central RussiaSci. Rep.202111152241:CAS:528:DC%2BB3MXlvF2gtLY%3D10.1038/s41598-021-84645-4336643517933364 MadsenTEKhouryJAlwellKSex-specific stroke incidence over time in the Greater Cincinnati/Northern Kentucky Stroke StudyNeurology2017891099099610.1212/WNL.0000000000004325287942545589794 MoskalenkoMIPonomarenkoIVVerzilinaINThe role of gene–gene and gene–environment interactions of polymorphic MMP loci in the formation of arterial hypertension in womenArter. Gipertenz.202026551852510.18705/1607-419X-2020-26-5-518-525 GhilardiGBiondiMLDeMontiMMatrix metalloproteinase- 1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosisStroke20023310240824121:CAS:528:DC%2BD38Xntlanu7g%3D10.1161/01.str.0000031929.05665.da12364729 GoriAMGiustiBPiccardiBInflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysisJ. Cereb. Blood Flow Metab.2017379325332611:CAS:528:DC%2BC1cXitFKmsr0%3D10.1177/0271678X17695572282668925584701 PolonikovAVPonomarenkoIVBykanovaMAA comprehensive study revealed SNP–SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension riskHypertens. Res.20194222572721:CAS:528:DC%2BC1cXisVylt7nO10.1038/s41440-018-0142-130518987 TE Madsen (1447_CR3) 2017; 89 AV Chobanian (1447_CR5) 2003; 289 1447_CR1 AN Britov (1447_CR12) 2011; 10 M Moskalenko (1447_CR7) 2021; 11 K Reynolds (1447_CR30) 2003; 289 AV Polonikov (1447_CR6) 2015; 33 G Zhang (1447_CR20) 2018; 27 S Barker-Collo (1447_CR4) 2015; 45 OA Osipova (1447_CR32) 2021; 20 AV Polonikov (1447_CR24) 2019; 42 AM Gori (1447_CR9) 2017; 37 R Jin (1447_CR18) 2010; 38 QW Zhang (1447_CR23) 2018; 14 1447_CR8 R Sherva (1447_CR22) 2011; 42 J Montaner (1447_CR11) 2019; 76 A Müller (1447_CR10) 2014; 41 1447_CR28 MM Hoeper (1447_CR13) 2013; 62 AV Polonikov (1447_CR15) 2021; 7 JH Zhao (1447_CR26) 2016; 14 B Vafadari (1447_CR17) 2016; 139 A Polonikov (1447_CR25) 2019; 120 G Ghilardi (1447_CR21) 2002; 33 K Chehaibi (1447_CR29) 2014; 342 MI Moskalenko (1447_CR19) 2020; 26 J Haorah (1447_CR33) 2008; 56 AS Go (1447_CR2) 2014; 129 MI Moskalenko (1447_CR14) 2018; 4 S Rivera (1447_CR16) 2010; 30 SM Clee (1447_CR27) 2010; 208 J Liu (1447_CR31) 2017; 148 |
References_xml | – volume: 208 start-page: 30 year: 2010 ident: 1447_CR27 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2009.09.019 contributor: fullname: SM Clee – volume: 42 start-page: 257 issue: 2 year: 2019 ident: 1447_CR24 publication-title: Hypertens. Res. doi: 10.1038/s41440-018-0142-1 contributor: fullname: AV Polonikov – volume: 56 start-page: 78 issue: 1 year: 2008 ident: 1447_CR33 publication-title: Glia doi: 10.1002/glia.20596 contributor: fullname: J Haorah – volume: 89 start-page: 990 issue: 10 year: 2017 ident: 1447_CR3 publication-title: Neurology doi: 10.1212/WNL.0000000000004325 contributor: fullname: TE Madsen – volume: 33 start-page: 2265 issue: 11 year: 2015 ident: 1447_CR6 publication-title: J. Hypertens. doi: 10.1097/HJH.0000000000000699 contributor: fullname: AV Polonikov – ident: 1447_CR8 doi: 10.17116/jnevro201911903211 – volume: 76 start-page: 3117 issue: 16 year: 2019 ident: 1447_CR11 publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-019-03175-5 contributor: fullname: J Montaner – volume: 342 start-page: 107 year: 2014 ident: 1447_CR29 publication-title: J. Neurol. Sci. doi: 10.1016/j.jns.2014.04.036 contributor: fullname: K Chehaibi – volume: 11 start-page: 5224 issue: 1 year: 2021 ident: 1447_CR7 publication-title: Sci. Rep. doi: 10.1038/s41598-021-84645-4 contributor: fullname: M Moskalenko – volume: 4 start-page: 53 issue: 1 year: 2018 ident: 1447_CR14 publication-title: Med. Farmatsiya doi: 10.18413/2313-8955-2018-4-1-53-69 contributor: fullname: MI Moskalenko – volume: 14 start-page: 19418 issue: 4 year: 2016 ident: 1447_CR26 publication-title: Genet. Mol. Res. doi: 10.4238/2015.December.30.3 contributor: fullname: JH Zhao – volume: 42 start-page: 34 issue: 2 year: 2011 ident: 1447_CR22 publication-title: Stroke doi: 10.1161/STROKEAHA.110.593798 contributor: fullname: R Sherva – ident: 1447_CR28 doi: 10.3390/jcm8112011 – volume: 38 start-page: 376 year: 2010 ident: 1447_CR18 publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2010.03.008 contributor: fullname: R Jin – volume: 26 start-page: 518 issue: 5 year: 2020 ident: 1447_CR19 publication-title: Arter. Gipertenz. doi: 10.18705/1607-419X-2020-26-5-518-525 contributor: fullname: MI Moskalenko – volume: 14 start-page: 419 year: 2018 ident: 1447_CR23 publication-title: Neuropsychiatr. Dis. Treat. doi: 10.2147/NDT.S152256 contributor: fullname: QW Zhang – volume: 37 start-page: 3253 issue: 9 year: 2017 ident: 1447_CR9 publication-title: J. Cereb. Blood Flow Metab. doi: 10.1177/0271678X17695572 contributor: fullname: AM Gori – volume: 62 start-page: 42 issue: 25 year: 2013 ident: 1447_CR13 publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2013.10.032 contributor: fullname: MM Hoeper – volume: 289 start-page: 579 issue: 5 year: 2003 ident: 1447_CR30 publication-title: JAMA doi: 10.1001/jama.289.5.579 contributor: fullname: K Reynolds – volume: 45 start-page: 203 issue: 3 year: 2015 ident: 1447_CR4 publication-title: Neuroepidemiology doi: 10.1159/000441103 contributor: fullname: S Barker-Collo – volume: 33 start-page: 2408 issue: 10 year: 2002 ident: 1447_CR21 publication-title: Stroke doi: 10.1161/01.str.0000031929.05665.da contributor: fullname: G Ghilardi – volume: 289 start-page: 2560 year: 2003 ident: 1447_CR5 publication-title: JAMA doi: 10.1001/jama.289.19.2560 contributor: fullname: AV Chobanian – ident: 1447_CR1 doi: 10.1161/01.str.21.4.637 – volume: 10 start-page: 57 issue: 6 year: 2011 ident: 1447_CR12 publication-title: Kardiovask. Ter. Profilakt. contributor: fullname: AN Britov – volume: 7 start-page: 15 issue: 1 year: 2021 ident: 1447_CR15 publication-title: Nauchn. Rezult. Biomed. Issled. doi: 10.18413/2658-6533-2020-7-1-0-2 contributor: fullname: AV Polonikov – volume: 27 start-page: 140 issue: 1 year: 2018 ident: 1447_CR20 publication-title: J. Stroke Cerebrovasc. Dis. doi: 10.1016/j.jstrokecerebrovasdis.2017.08.021 contributor: fullname: G Zhang – volume: 139 start-page: 91 issue: Suppl. 2 year: 2016 ident: 1447_CR17 publication-title: J. Neurochem. doi: 10.1111/jnc.13415 contributor: fullname: B Vafadari – volume: 129 start-page: e28 year: 2014 ident: 1447_CR2 publication-title: Circulation doi: 10.1161/01.cir.0000441139.02102.80 contributor: fullname: AS Go – volume: 41 start-page: 562 issue: 7 year: 2014 ident: 1447_CR10 publication-title: Nucl. Med. Biol. doi: 10.1016/j.nucmedbio.2014.04.085 contributor: fullname: A Müller – volume: 148 start-page: 355 year: 2017 ident: 1447_CR31 publication-title: Prog. Mol. Biol. Transl. Sci. doi: 10.1016/bs.pmbts.2017.04.003 contributor: fullname: J Liu – volume: 30 start-page: 15337 issue: 46 year: 2010 ident: 1447_CR16 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3467-10.2010 contributor: fullname: S Rivera – volume: 20 start-page: 3087 issue: 8 year: 2021 ident: 1447_CR32 publication-title: Kardiovask. Ter. Profilakt. doi: 10.15829/1728-8800-2021-3087 contributor: fullname: OA Osipova – volume: 120 start-page: 16467 year: 2019 ident: 1447_CR25 publication-title: J. Cell. Biochem. doi: 10.1002/jcb.28815 contributor: fullname: A Polonikov |
SSID | ssj0007780 |
Score | 2.3242328 |
Snippet | Objectives.
To analyze the role of genetic polymorphisms of matrix metalloproteinase (
MMP
) genes and their gene–gene and gene–environment interactions in the... Objectives. To analyze the role of genetic polymorphisms of matrix metalloproteinase (MMP) genes and their gene–gene and gene–environment interactions in the... |
SourceID | proquest crossref springer |
SourceType | Aggregation Database Publisher |
StartPage | 496 |
SubjectTerms | Alcohol abuse Behavioral Sciences Biomedical and Life Sciences Biomedicine Chromosome 11 Drug abuse Environmental factors Gene polymorphism Genes Haplotypes Hypertension Ischemia Matrix metalloproteinase Metalloproteinase Neurobiology Neurosciences Single-nucleotide polymorphism Stroke |
SummonAdditionalLinks | – databaseName: Proquest Health & Medical Complete dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NbtQwELZKkRCXCloQSwvyAXEBa_O7dk7VgrpaEEGoUGlvkX_Ralun3U2ldk-8A0_Fa_AkzDgJEUhwihI7jpVv7Jmx5xsT8iISVtpM5kw7pVkGOpTJTDhmnXQwH8oJd0gULj9O5mfZ-0W-2CHznguDYZX9nBgmalNrXCMfwzSapxlSI8dS4SqAbsbHl1cMz4_CfdbuMI075G6cgFkBks0Xv12viHPRklEw9yi4RB19piXR4RmRDHQXQ--Cs-2fKmqwO__aKg0aaPaA7HWmI522WD8kO9bvk4OpB7f54pa-pCGYM6yS75N7ZbdnfkB-gCTQ0_rc0tpRMPcoZpr--e07Xqj0pr8_GShvNKwTtpSHDb72qT6_vagBkqWmHwBOfFZicv8bWtoG9-5DvoelB524oUtPZzXG2HwN3ztdblb4wjtwpDEUn35u1vUKuuND8RupV8gtgZ5ApSmGmMKYoHNwkNchvB7qQYul9Y_I2ezky9s56w5wYBrMgC3TueKxhp9si1xlfMJtbnTunFaxAtVpXeScjKU1WVxwian5ZCrAPksSIfTE2PQx2fW1t08ITUzOC13kNjVRpkyhpBFOuDgqtEuFViPyqsesumzzdFRDRmZEuAKEq4BwtR2Rox7Wqhuzm2qQsBF53UM9FP-7taf_b-2Q3E-CdGGU5BHZbdbX9hlYMo16HoT0F1gp9n0 priority: 102 providerName: ProQuest |
Title | The Role of the Gene–Gene and Gene–Environment Interactions of Polymorphic Loci of Matrix Metalloproteinases in Forming the Risk of Ischemic Stroke on the Background of Arterial Hypertension in Men |
URI | https://link.springer.com/article/10.1007/s11055-023-01447-z https://www.proquest.com/docview/2845340647/abstract/ |
Volume | 53 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NjtMwELbYXQlxQbALorBUPiAuYKn5ce0cU9RSflKtCpXKKbIdG1XddVBbJLYn3oGn4jV4EmbchAgEB05W4p9Y_hzPjD3fmJAnA2mVTRVnxmnDUpChTKXSMeuUg_VQDYVDonAxG04X6eslX3Y87uDs3p5IhoW647rhVY4MRAxDI0Cw_RE5QeUBp_Iizn8tv0LIA-8Ew4yC9dMwZf7exu_SqFMx_zgVDcJmcofcbrREmh9gvUtuWH9KznIPFvLVNX1Kg99m2BA_JTeL5nj8jHwH0Om8vrS0dhQ0O4pBpX98_YYJVb5qn8cdu42GLcEDu2GL1S7qy-urGkZ_ZehbQA7fFRjH_wst7A6P6UNoh5UH8belK08nNbrTfAzfm6-2a6zwCmxm9Lqn73abeg3d8SF7pMwaaSTQEyiUozcpTH86BVt4EzzpoRy0WFh_jywm4_cvpqy5q4EZkPh7ZrgWkYFBthnXqRgKyyvDnTM60iAlrRs4pyJlqzTKhMIofCqRoIrFsZRmWNnkPjn2tbcPCI0rLjKTcZtUg1RXmVaVdNJFg8y4RBrdI89azMpPh5AcZRd8GREuAeEyIFzue-S8hbVsfs9tCTKZJynybHvkeQt1l_3v1h7-X_FH5FYcZhs6SJ6T493ms30MSsxO98mRWIo-Ockno9EM05cf3owhHY1nF_N-mNI_AX-79VE |
link.rule.ids | 315,786,790,12083,21416,27957,27958,31754,33779,41116,41558,42185,42627,43345,43840,52146,52269,74102,74659 |
linkProvider | Springer Nature |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dbtMwFLagk4AbBBuIwgBfIG7AomnsOrlCHWrVQVNNZZN2F9mOjapuyWiKxHrFO_BUvAZPwjmOQwQSXEWJHcfKd3x-7PNDyItBYpXlSjDjtGEcZChTPHHMOuWAH6qRdBgonC1GszP-_lychw23OrhVtjzRM-qiMrhH_gbYqIg5hka-vfrMsGoUnq6GEho3yR6PwVTpkb2jyeJk-ZsXS5k0QSiYcxRMoRA20wTPYW1IBjKLoVUh2e5P0dTpm38dkXrJM71H7gaVkY4bjO-TG7bcJwfjEszly2v6knonTr87vk9uZeGs_ID8AAqgy-rC0spRUPMoZpj--e07Xqgqi_Z-0oW6Ub8_2IQ61PjaSXVxfVkBFCtD5wAjPsswqf9Xmtktntn7PA-rEmRhTVclnVboW_PJf2-5qtf4wjEY0OiCTz9uN9UaplP65iNl1hhTAjOBTmN0LYW1QGdgGG-8Wz30gxEzWz4gZ9PJ6bsZC4UbmAHxv2NGaBkZ-Mk2FZrLkbSiMMI5oyMNItO6gXMqUrbgUSoVpuRTgB6PhsMkMaPCxg9Jr6xK-4jQYSFkalJh42LAdZFqVSQucdEgNS5OjO6TVy1m-VWTnyPvMjEjwjkgnHuE812fHLaw5mGt1nlHWX3yuoW6a_73aI__P9pzcnt2ms3z-fHiwxNyZ-gpDT0lD0lvu_lin4I2s9XPAsn-Anj39xY |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dbtMwFLZgkyZuEGwgCmP4AnED1pomjpMr1I1WHSxVVZi0u8hx7Knq5oymSKxXvMOeaq_Bk3CO4xCBBFdREseJ8h2fH_s7x4S87ida6khypkyhWAQ2lMkoMUwbaUAfylgYTBTOpvHkLPp4zs89_6n2tMpWJzpFXVYK58gPQY3yMMLUyEPjaRGzD-P3118Z7iCFK61-O437ZFtEMQcJ3z4aTWfz33pZiKRJSMH6oxAW-RSaJpEO94lkYL8YRhiCbf40U53v-ddyqbNC40fkoXcf6bDB-zG5p-0u2RtaCJ2vbugb6gidbqZ8l-xkft18j9yBNNB5dalpZSi4fBSrTf_8cYsHKm3Zno-6tDfq5gqbtIcaH5tVlzdXFcCyUPQUIMVrGRb4_04zvcb1e1fzYWHBLtZ0Yem4Qp7NhXvffFEv8YETCKaRjk8_r1fVEj7HuttHUi0xvwS-BBoNkWYK44JOIEheOYo9tIMeM22fkLPx6MvxhPlNHJgCV2DDFC9EoOAn65QXkYiF5qXixqgiKMB8atM3RgZSl1GQConl-WSYgI82GCSJiksdPiVbtrL6GaGDkotUpVyHZT8qyrSQZWISE_RTZcJEFT3ytsUsv25qdeRdVWZEOAeEc4dwvumR_RbW3I_bOu-krEfetVB3t__d2_P_9_aK7IC05qcn008vyIOBEzQkTe6TrfXqm34Jjs26OPAS-wv02PtT |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Role+of+the+Gene%E2%80%93Gene+and+Gene%E2%80%93Environment+Interactions+of+Polymorphic+Loci+of+Matrix+Metalloproteinases+in+Forming+the+Risk+of+Ischemic+Stroke+on+the+Background+of+Arterial+Hypertension+in+Men&rft.jtitle=Neuroscience+and+behavioral+physiology&rft.au=Kalinina%2C+M.+I.&rft.au=Ponomarenko%2C+I.+V.&rft.au=Efremova%2C+O.+A.&rft.au=Batlutskaya%2C+I.+V.&rft.date=2023-05-01&rft.issn=0097-0549&rft.eissn=1573-899X&rft.volume=53&rft.issue=4&rft.spage=496&rft.epage=502&rft_id=info:doi/10.1007%2Fs11055-023-01447-z&rft.externalDBID=n%2Fa&rft.externalDocID=10_1007_s11055_023_01447_z |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0097-0549&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0097-0549&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0097-0549&client=summon |