Histamine H 2 receptor activity during the differentiation of the human monocytic-like cell line U-937 : Comparison with prostaglandins and isoproterenol

• Published in: FEBS letters Vol. 184; no. 2; pp. 207 - 213
• Main Authors: Gespach, Christian, Cost, Hélène, Abita, Jean-Pierre
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.1985
• Subjects: Histamine H 2 receptor Monocytic differentiation U-937 cell Monocyte-Macrophage-like cell; Histamine H 2 receptor Monocytic differentiation U-937 cell Monocyte-Macrophage-like cell

Histamine H 2 receptor activity (cAMP generation) has been characterized in U-937 cells before and after retinoic acid-induced differentiation into monocyte-/macrophage-like cells. The differentiation is associated with a decreased capacity of U-937 monocytes to generate cAMP under basal conditions...