Efficacy of Ibrutinib, Rituximab and Mini-CHOP in Very Elderly Patients with Newly Diagnosed Diffuse Large B Cell Lymphoma: Primary Analysis of the Australasian Leukaemia & Lymphoma Group NHL29 Study

• Published in: Blood Vol. 138; no. Supplement 1; p. 304
• Main Authors: Verner, Emma, Johnston, Amanda, Pati, Nalini, Hawkes, Eliza, Lee, Hui-Peng, Cochrane, Tara, Cheah, Chan-Yoon, Filshie, Robin J, Purtill, Duncan, Sia, Hanlon, Enjeti, Anoop Kumar, Brown, Christina, Murphy, Nicholas E., Curnow, Jennifer, Lee, Kenneth, Walia, Mannu, Butcher, Belinda, Trotman, Judith
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 23.11.2021

Introduction R-mini-CHOP is an established standard of care in elderly patients with DLBCL, with a 2yr OS of 59% and PFS of 47% (Peyrade et al, Lancet Oncol 2011). The addition of ibrutinib to full dose R-CHOP in younger pts with DLBCL has efficacy, but significant toxicity limits the ability to com...