The Binding of CD38 Therapeutics to Red Blood Cells and Platelets Subverts Depletion of Target Cells

• Published in: Blood Vol. 134; no. Supplement_1; p. 3136
• Main Authors: Fedyk, Eric Robert, Idamakanti, Neeraja, Chen, Jia, Estevam, Jose, Hernandez, Vivian, Wagoner, Matthew, Carsillo, Mary, Berg, Deborah, Allikmets, Kristina, Lahu, Gezim, Palumbo, Antonio
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 13.11.2019

Introduction: The CD38 antigen is a target for treating multiple myeloma and is being investigated for disorders caused by plasma cells. Therapeutics bind to CD38 on red blood cells and platelets in the vasculature, prior to myeloma and plasma cells in the bone marrow and this initial activity could...