HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription

• Published in: Blood Vol. 138; no. Supplement 1; p. 571
• Main Authors: Huang, Peng, Peslak, Scott A., Khandros, Eugene, Lan, Xianjiang, Qin, Kunhua, Sharma, Malini, Keller, Cheryl A., Giardine, Belinda, Abdulmalik, Osheiza, Chou, Stella T., Shi, Junwei, Hardison, Ross C., Blobel, Gerd A.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 23.11.2021

One of the oldest and most deeply studied problems in developmental gene expression is the switch from fetal to adult type hemoglobin production in red blood cell precursors. Interest in this question has been fueled by its relevance to genetic blood disorders such as sickle cell disease (SCD) and t...