DOFETILIDE EFFICACY AND SAFETY PROFILE IN OFF-LABEL USE

Dofetilide was discontinued in 20 patients (15%) during the initiation admission and in 21 patients (16%) within 6 weeks of initiation (24 due to inefficacy, 9 with excessive QT prolongation, 4 with Torsades de Pointes, 3 unable to afford the medication, and 1 with worsening renal function).

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Bibliographic Details
Published inJournal of the American College of Cardiology Vol. 59; no. 13; p. E683
Main Authors Brumberg, Genevieve E, Gera, Nitin, Adelstein, Evan, Saba, Samir, Jain, Sandeep
Format Journal Article
LanguageEnglish
Published New York Elsevier Inc 27.03.2012
Elsevier Limited
Subjects
Cardiac arrhythmia
Cardiology
Cardiovascular
Drug therapy
Internal Medicine
Medical research
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Summary:Dofetilide was discontinued in 20 patients (15%) during the initiation admission and in 21 patients (16%) within 6 weeks of initiation (24 due to inefficacy, 9 with excessive QT prolongation, 4 with Torsades de Pointes, 3 unable to afford the medication, and 1 with worsening renal function).
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(12)60684-6