P95: Effect of Chronic Inflammation Inhibition with Salsalate on Aortic Stiffness and Vascular Endothelial Function in Older Adults: A Randomized Controlled Study

• Published in: Artery research Vol. 20; no. 1; pp. 88 - 89
• Main Authors: Pierce, Gary, DuBose, Lyndsey, Stroud, Amy, Jensen, Nicholas, Wegman-Points, Lauren, Holwerda, Seth, Haynes, William, Dubishar, Kaitlyn, Fiedorowicz, Jess
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2017; Springer Nature B.V; BMC
• Subjects: ARTERY 17 Poster Presentation abstracts; Older people

Chronic activation of the proinflammatory transcription factor nuclear factor kappa-B (NFkB) is linked to age-associated vascular dysfunction. Acute inhibition of NFkB with high-dose salsalate (>4g), a non-acetylated salicylate known to block NFkB activation, improves aortic stiffness and endothe...