Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

• Published in: bioRxiv
• Main Authors: Maynard, Kristen E, Collado-Torres, Leonardo, Weber, Lukas M, Uytingco, Cedric, Barry, Brianna K, Williams, Stephen R, Catallini, Joseph L, Tran, Matthew N, Besich, Zachary, Tippani, Madhavi, Chew, Jennifer, Yin, Yifeng, Kleinman, Joel E, Hyde, Thomas M, Rao, Nikhil, Hicks, Stephanie C, Martinowich, Keri, Jaffe, Andrew E
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 28.02.2020
• Subjects: Autism; Brain architecture; Gene expression; Genomics; Mental disorders; Nervous system; Prefrontal cortex; Ribonucleic acid; RNA; Schizophrenia; Transcriptomics

We used the 10x Genomics Visium platform to define the spatial topography of gene expression in the six-layered human dorsolateral prefrontal cortex (DLPFC). We identified extensive layer-enriched expression signatures, and refined associations to previous laminar markers. We overlaid our laminar ex...