Targeting Intracellular WT1 in AML Utilizing a T Cell Bispecific Antibody Construct: Augmenting Efficacy through Combination with Lenalidomide

• Published in: Blood Vol. 134; no. Supplement_1; p. 4450
• Main Authors: Klein, Christian, Augsberger, Christian, Xu, Wei, Heitmüller, Christina, Hanisch, Lydia, Sam, Johannes, Pulko, Vesna, Schönle, Anne, Challier, John, Carpy, Alejandro, Konstandin, Nikola, Rothe, Maurine, Hänel, Gerulf, Bücklein, Veit, Lichtenegger, Felix S., Tunger, Antje, Schmitz, Marc, von Bergwelt, Michael, Spiekermann, Karsten, Umana, Pablo, Subklewe, Marion
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 13.11.2019

Antibody-based immunotherapy represents a promising strategy to target chemo-resistant leukemic cells. However, current antibody-based approaches are restricted to cell lineage surface antigens. Targeting intracellular antigens enables to enlarge the number of suitable tumor-associated target antige...