PerR: A Peroxide Sensor Eliciting Metal Ion-dependent Regulation in Various Bacteria

Bacteria have to thrive in difficult conditions wherein their competitors generate partially reduced forms of oxygen, like hydrogen peroxide and superoxides. These oxidative stress molecules can also arise from within via the autoxidation of redox enzymes. To adapt to such conditions, bacteria expre...

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Bibliographic Details
Published inMolecular biotechnology
Main Authors Kandari, Divya, Joshi, Hemant
Format Journal Article
LanguageEnglish
Published Switzerland 18.09.2024
Subjects
Oxidative stress
Metalloregulator
Pathogenic bacteria
Transcription factor
Virulence
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Summary:Bacteria have to thrive in difficult conditions wherein their competitors generate partially reduced forms of oxygen, like hydrogen peroxide and superoxides. These oxidative stress molecules can also arise from within via the autoxidation of redox enzymes. To adapt to such conditions, bacteria express detox enzymes as well as repair proteins. Transcription factors regulate these defenses, and PerR is one of them. PerR is a Fur family transcriptional regulator that senses peroxide stress. Metal-bound PerR (either Mn or Fe ) can repress transcription of its regulon, but only the Fe -bound form of PerR can sense H O . This review describes different aspects of PerR and its varied roles, specifically in bacterial pathogens. Despite having roles beyond sensing peroxides, it is an underrated regulator that needs to be explored more deeply in pathogens.
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ISSN:1073-6085
1559-0305
1559-0305
DOI:10.1007/s12033-024-01266-8