HLA evolutionary divergence (HED) informs the effect of HLA-B mismatch on outcomes after haploidentical transplantation

• Published in: Bone marrow transplantation (Basingstoke)
• Main Authors: Solh, Melhem, Aubrey, Michael T, Zhang, Xu, Bashey, Asad, Freed, Brian M, Roark, Christina L, Bachier-Rdriguez, Lizamarie, Morris, Lawrence E, Kent Holland, H, Solomon, Scott R
• Format: Journal Article
• Language: English
• Published: England 31.07.2024

Graft versus tumor relies on tumor-associated antigens (TAAs) that are presented to donor T cells via human leukocyte antigens (HLAs). The HLA evolutionary divergence (HED) between alleles of a single individual can dictate the ability to present TAAs. The impact of HED in haploidentical donor trans...