TGF-β3-mediated phagocytosis protects mammary epithelial cells of ketotic dairy cows against metabolic stress–induced inflammatory damage

• Published in: Journal of dairy science
• Main Authors: Chang, Renxu, Jia, Hongdou, Chen, Yuanyuan, Loor, Juan J., Xu, Qiushi, Ma, Li, Li, Ming, Shen, Taiyu, Li, Xiaobing, Xu, Chuang, Sun, Xudong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 31.07.2025
• Subjects: bovine mammary epithelial cells; inflammatory response; ketosis; phagocytosis; TGF-β3; inflammatory response; phagocytosis; bovine mammary epithelial cells; ketosis; TGF-β3

The supraphysiological levels of free fatty acids (FFA) during early lactation led to an inflammatory response in the mammary gland of ketotic cows, which may be attributed to the untimely clearance of apoptotic cells (AC). Given the engulfment role of mammary epithelial cells for AC and the regulat...