Introduction of a β-leucine residue instead of leucine9 and glycine10 residues in Temporin L for improved cell selectivity, stability and activity against planktonic and biofilm of methicillin resistant S. aureus

• Published in: Bioorganic chemistry Vol. 134; p. 106440
• Main Authors: Verma, Neeraj Kumar, Dewangan, Rikeshwer Prasad, Harioudh, Munesh Kumar, Ghosh, Jimut Kanti
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.05.2023
• Subjects: Antimicrobial peptide; Methicillin resistant S. aureus; MRSA biofilm; Temporin L; β-leucine; DiSC3; PC; AMP; MRSA; PG; TL; Fmoc; Temporin L; Methicillin resistant S. aureus; β-leucine; MRSA biofilm; Antimicrobial peptide

[Display omitted] •L9βl-TL showed higher proteolytic stability, therapeutic index and activity against MRSA biofilm than Temporin-L (TL).•Though unordered in bacterial membrane-mimetic lipid vesicles, L9βl-TL depolarized these vesicles and live MRSA.•The results show the design of a TL-analogue with...