Front Cover: Development of Fluorophosphoramidate as a Biocompatibly Transformable Functional Group and its Application as a Phosphate Prodrug for Nucleoside Analogs (ChemMedChem 17/2022)

• Published in: ChemMedChem Vol. 17; no. 17
• Main Authors: Yoshida, Yuki, Zheng, Ti, Tanabe, Wataru, Tomoike, Fumiaki, Hashiya, Fumitaka, Suzuki, Tetsuro, Hirota, Shuto, Saiki, Yuriko, Horii, Akira, Hirayama, Akiyoshi, Soga, Tomoyosi, Kimura, Yasuaki, Abe, Hiroshi
• Format: Journal Article
• Language: English; Japanese
• Published: Wiley 05.09.2022
• Subjects: anti-cancer drugs; antiviral drugs; nucleoside analogs; phosphate; prodrugs

The Front Cover shows a new type of biocompatible phosphate analog, a fluorophosphoramidate (FPA) functional group with characteristic P–F and P–N bonds. The stability of the FPA group was found to vary depending on the number of the amino group substitutions. Taking advantage of this intriguing mol...