Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories

• Published in: The Neuroscientist (Baltimore, Md.) p. 10738584241268754
• Main Authors: Parmaksiz, Deniz, Kim, Yongsoo
• Format: Journal Article
• Language: English
• Published: United States 07.08.2024
• Subjects: blood-brain barrier; neuroendocrinology; perivascular space; oxytocin; circumventricular organs; volume transmission; transport mechanism; somatodendritic release; axonal release; neurohypophyseal system; neurovasculature; cerebrospinal fluid; hypothalamus

Complex mechanisms govern the transport and action of oxytocin (Oxt), a neuropeptide and hormone that mediates diverse physiologic processes. While Oxt exerts site-specific and rapid effects in the brain via axonal and somatodendritic release, volume transmission via CSF and the neurovascular interf...