Effect of partial liquid ventilation on oleic acid-induced inflammatory responses in piglets

• Published in: Chinese medical journal Vol. 123; no. 15; pp. 2088 - 2093
• Main Authors: Zhu, Yao-bin, Wang, Qiang, Liu, Ying-long, Li, Xiao-feng, Li, Jian-an, Lü, Xiao-dong, Ling, Feng, Liu, Ai-jun, Fan, Xiang-ming
• Format: Journal Article
• Language: English
• Published: China Department of Pediatric Cardiac Surgery Center, Fu Wai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China 05.08.2010
• Subjects: Animals; Fluorocarbons - therapeutic use; Hemodynamics - drug effects; Inflammation - chemically induced; Inflammation - therapy; Interleukin-10 - metabolism; Interleukin-1beta - metabolism; Interleukin-6 - metabolism; Liquid Ventilation - methods; Lung Injury - immunology; Lung Injury - therapy; Oleic Acid - toxicity; Random Allocation; Respiration, Artificial; Swine; Tumor Necrosis Factor-alpha - metabolism; 二氧化碳分压; 急性肺损伤; 损伤模型; 机械通气; 炎症反应; cytokine; acute respiratory distress syndrome; inflammatory response; piglets; partial liquid ventilations
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2010.15.024

Background Pediatric patients are susceptible to lung injury.Acute lung injury （ALI） in children often results in a high mortality.Partial liquid ventilation （PLV） has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury models.This study aimed to examine the hypothesis that PLV would attenuate the production of local and systemic cytokines in an immature piglet model of ALI induced by oleic acid （OA）.Methods Twelve Chinese immature piglets were induced to develop ALI by oleic acid.The animals were randomly assigned to two groups （n=6）： （1） conventional mechanical ventilation （MV） group and （2） PLV with FC-77 （10 ml/kg） group.Results Compared with MV group, PLV group got better cardiopulmonary variables （P 〈0.05）.These variables included heart rate, mean blood pressure, blood pH, partial pressure of arterial oxygen （PaO2）, PaO2/FiO2 and partial pressure of arterial carbon dioxide （PaCO2）.Partial liquid ventilation reduced IL-1β, IL-6, IL-10 and TN F-α both in plasma and tissue concentrations compared with MV group （P 〈0.05）.Conclusions Partial liquid ventilation provides protective effects against inflammatory responses in the lungs of oleic acid-induced immature piglets.