Joint system relaxometry (JSR) and Crámer‐Rao lower bound optimization of sequence parameters: A framework for enhanced precision of DESPOT T 1 and T 2 estimation

• Published in: Magnetic resonance in medicine Vol. 79; no. 1; pp. 234 - 245
• Main Authors: Teixeira, Rui Pedro A.G., Malik, Shaihan J., Hajnal, Joseph V.
• Format: Journal Article
• Language: English
• Published: United States 01.01.2018
• Subjects: Adult; Algorithms; Brain - diagnostic imaging; Calibration; Computer Simulation; Female; Healthy Volunteers; Humans; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Magnetic Resonance Spectroscopy; Male; Models, Statistical; Phantoms, Imaging; Reproducibility of Results; Signal-To-Noise Ratio; Young Adult; CRLB; relaxometry; DESPOT

This study aims to increase the precision of single-compartment DESPOT relaxometry by two means: (i) a joint system relaxometry (JSR) approach that estimates parameters in a single step using all available data; and (ii) optimizing acquisition parameters by deploying a robust design tool based on th...