Repair gene O 6 ‐methylguanine‐DNA methyltransferase is controlled by SP1 and up‐regulated by glucocorticoids, but not by temozolomide and radiation - Aasland, Dorthe; Reich, Thomas R.; Tomicic, Maja T.; Switzeny, Olivier J.; Kaina, Bernd; Christmann, Markus (Journal of neurochemistry, 2018)
Keywords: Antineoplastic Agents, Alkylating - pharmacology; Dexamethasone - pharmacology; DNA Repair Enzymes - drug effects; DNA Repair Enzymes - genetics; DNA Repair Enzymes - radiation effects; Enzyme Induction - drug effects; Enzyme Induction - radiation effects; Gene Knockdown Techniques; Glucocorticoids - pharmacology; Humans; O-Methylguanine-DNA Methyltransferase - drug effects; O-Methylguanine-DNA Methyltransferase - genetics; O-Methylguanine-DNA Methyltransferase - radiation effects; Promoter Regions, Genetic - genetics; RNA, Messenger - pharmacology; Sp1 Transcription Factor - drug effects; Sp1 Transcription Factor - genetics; Sp1 Transcription Factor - radiation effects; Temozolomide - pharmacology; Up-Regulation - drug effects; Up-Regulation - radiation effects; temozolomide; glioblastoma; MGMT; transcriptional regulation; ionizing radiation