V 1b vasopressin receptor trafficking and signaling: Role of arrestins, G proteins and Src kinase

• Published in: Traffic (Copenhagen, Denmark) Vol. 19; no. 1; pp. 58 - 82
• Main Authors: Perkovska, Sanja, Méjean, Catherine, Ayoub, Mohammed Akli, Li, Juan, Hemery, Floriane, Corbani, Maithé, Laguette, Nadine, Ventura, Maria-Angeles, Orcel, Hélène, Durroux, Thierry, Mouillac, Bernard, Mendre, Christiane
• Format: Journal Article
• Language: English
• Published: England 01.01.2018
• Subjects: Animals; beta-Arrestins - chemistry; beta-Arrestins - metabolism; Binding Sites; GTP-Binding Proteins - metabolism; HEK293 Cells; Humans; MAP Kinase Signaling System; Mice; Protein Binding; Protein Transport; Receptors, Vasopressin - metabolism; src-Family Kinases - metabolism; BRET; V1b and V2 vasopressin receptors; signal transduction; mitogen-activated protein kinase (MAPK); Src kinase; intracellular trafficking; FRET; G-protein-coupled receptor (GPCR); arrestin; biased signaling; DERET

The signaling pathway of G protein-coupled receptors is strongly linked to their trafficking profile. Little is known about the molecular mechanisms involved in the vasopressin receptor V subtype (V R) trafficking and its impact on receptor signaling and regulation. For this purpose, we investigated...