Capillary blood protein markers of posttraumatic headache in children after concussion
Posttraumatic headache (PTH) represents the most common acute and persistent symptom in children after concussion, yet there is no blood protein signature to stratify the risk of PTH after concussion to facilitate early intervention. This discovery study aimed to identify capillary blood protein mar...
Saved in:
Published in | Journal of neurosurgery. Pediatrics p. 1 |
---|---|
Main Authors | , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.06.2024
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Posttraumatic headache (PTH) represents the most common acute and persistent symptom in children after concussion, yet there is no blood protein signature to stratify the risk of PTH after concussion to facilitate early intervention. This discovery study aimed to identify capillary blood protein markers, at emergency department (ED) presentation within 48 hours of concussion, to predict children at risk of persisting PTH at 2 weeks postinjury.
Capillary blood was collected using the Mitra Clamshell device from children aged 8-17 years who presented to the ED of the Royal Children's Hospital, Melbourne, Australia, within 48 hours of sustaining a concussion. Participants were followed up at 2 weeks postinjury to determine PTH status. PTH was defined per clinical guidelines as a new or worsened headache compared with preinjury. An untargeted proteomics analysis using data-independent acquisition (DIA) was performed. Principal component analysis and hierarchical clustering were used to reduce the dimensionality of the protein dataset.
A total of 907 proteins were reproducibly identified from 82 children within 48 hours of concussion. The mean participant age was 12.78 years (SD 2.54 years, range 8-17 years); 70% of patients were male. Eighty percent met criteria for acute PTH in the ED, while one-third of participants with follow-up experienced PTH at 2 weeks postinjury (range 8-16 days). Hemoglobin subunit zeta (HBZ), cystatin B (CSTB), beta-ala-his dipeptidase (CNDP1), hemoglobin subunit gamma-1 (HBG1), and zyxin (ZYX) were weakly associated with PTH at 2 weeks postinjury based on up to a 7% increase in the PTH group despite nonsignificant Benjamini-Hochberg adjusted p values.
This discovery study determined that no capillary blood protein markers, measured at ED presentation within 48 hours of concussion, can predict children at risk of persisting PTH at 2 weeks postinjury. While HBZ, CSTB, CNDP1, HBG1, and ZYX were weakly associated with PTH at 2 weeks postinjury, there was no specific blood protein signature predictor of PTH in children after concussion. There is an urgent need to discover new blood biomarkers associated with PTH to facilitate risk stratification and improve clinical management of pediatric concussion. |
---|---|
AbstractList | Posttraumatic headache (PTH) represents the most common acute and persistent symptom in children after concussion, yet there is no blood protein signature to stratify the risk of PTH after concussion to facilitate early intervention. This discovery study aimed to identify capillary blood protein markers, at emergency department (ED) presentation within 48 hours of concussion, to predict children at risk of persisting PTH at 2 weeks postinjury.
Capillary blood was collected using the Mitra Clamshell device from children aged 8-17 years who presented to the ED of the Royal Children's Hospital, Melbourne, Australia, within 48 hours of sustaining a concussion. Participants were followed up at 2 weeks postinjury to determine PTH status. PTH was defined per clinical guidelines as a new or worsened headache compared with preinjury. An untargeted proteomics analysis using data-independent acquisition (DIA) was performed. Principal component analysis and hierarchical clustering were used to reduce the dimensionality of the protein dataset.
A total of 907 proteins were reproducibly identified from 82 children within 48 hours of concussion. The mean participant age was 12.78 years (SD 2.54 years, range 8-17 years); 70% of patients were male. Eighty percent met criteria for acute PTH in the ED, while one-third of participants with follow-up experienced PTH at 2 weeks postinjury (range 8-16 days). Hemoglobin subunit zeta (HBZ), cystatin B (CSTB), beta-ala-his dipeptidase (CNDP1), hemoglobin subunit gamma-1 (HBG1), and zyxin (ZYX) were weakly associated with PTH at 2 weeks postinjury based on up to a 7% increase in the PTH group despite nonsignificant Benjamini-Hochberg adjusted p values.
This discovery study determined that no capillary blood protein markers, measured at ED presentation within 48 hours of concussion, can predict children at risk of persisting PTH at 2 weeks postinjury. While HBZ, CSTB, CNDP1, HBG1, and ZYX were weakly associated with PTH at 2 weeks postinjury, there was no specific blood protein signature predictor of PTH in children after concussion. There is an urgent need to discover new blood biomarkers associated with PTH to facilitate risk stratification and improve clinical management of pediatric concussion. |
Author | Yousef, Jumana Fabiano, Fabian Anderson, Nicholas Emery-Corbin, Samantha J Babl, Franz E Ignjatovic, Vera Anderson, Vicki Seal, Marc Fan, Feiven Dagley, Laura F Parkin, Georgia M Takagi, Michael Hearps, Stephen J C Rausa, Vanessa C Dunne, Kevin Swaney, Ella E K Davis, Gavin A Attard, Chantal |
Author_xml | – sequence: 1 givenname: Feiven surname: Fan fullname: Fan, Feiven organization: 2Melbourne School of Psychological Sciences, University of Melbourne, Victoria – sequence: 2 givenname: Franz E surname: Babl fullname: Babl, Franz E organization: 5Emergency Department, Royal Children's Hospital, Melbourne, Victoria – sequence: 3 givenname: Ella E K surname: Swaney fullname: Swaney, Ella E K organization: Departments of3Pediatrics – sequence: 4 givenname: Stephen J C surname: Hearps fullname: Hearps, Stephen J C organization: 4Critical Care, and – sequence: 5 givenname: Michael surname: Takagi fullname: Takagi, Michael organization: 6Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Victoria – sequence: 6 givenname: Samantha J surname: Emery-Corbin fullname: Emery-Corbin, Samantha J organization: 8Medical Biology, University of Melbourne, Victoria – sequence: 7 givenname: Laura F surname: Dagley fullname: Dagley, Laura F organization: 8Medical Biology, University of Melbourne, Victoria – sequence: 8 givenname: Jumana surname: Yousef fullname: Yousef, Jumana organization: 8Medical Biology, University of Melbourne, Victoria – sequence: 9 givenname: Georgia M surname: Parkin fullname: Parkin, Georgia M organization: 1Murdoch Children's Research Institute, Melbourne, Victoria – sequence: 10 givenname: Vanessa C surname: Rausa fullname: Rausa, Vanessa C organization: Departments of3Pediatrics – sequence: 11 givenname: Nicholas surname: Anderson fullname: Anderson, Nicholas organization: 1Murdoch Children's Research Institute, Melbourne, Victoria – sequence: 12 givenname: Fabian surname: Fabiano fullname: Fabiano, Fabian organization: 2Melbourne School of Psychological Sciences, University of Melbourne, Victoria – sequence: 13 givenname: Kevin surname: Dunne fullname: Dunne, Kevin organization: 9Department of Rehabilitation Medicine, Royal Children's Hospital, Melbourne, Victoria – sequence: 14 givenname: Marc surname: Seal fullname: Seal, Marc organization: Departments of3Pediatrics – sequence: 15 givenname: Gavin A surname: Davis fullname: Davis, Gavin A organization: 10Department of Neurosurgery, Austin and Cabrini Hospitals, Melbourne, Victoria – sequence: 16 givenname: Chantal surname: Attard fullname: Attard, Chantal organization: Departments of3Pediatrics – sequence: 17 givenname: Vicki surname: Anderson fullname: Anderson, Vicki organization: 11Psychology Service, Royal Children's Hospital, Melbourne, Victoria, Australia – sequence: 18 givenname: Vera surname: Ignjatovic fullname: Ignjatovic, Vera organization: 13Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38457794$$D View this record in MEDLINE/PubMed |
BookMark | eNo1j81KxDAYRYMozo_uXUleoDXJlzTNUsYZFQYU_NkOafqVRtumJO1i3t4BdXU3h8O5K3I-hAEJueEsB675nWBC5iJ_3T68CVCKn5ElNwAZ01wtyCqlL8akkIZfkgWUUmlt5JJ8buzou87GI626EGo6xjChH2hv4zfGRENDx5CmKdq5t5N3tEVbW9ciPUGu9V0dcaC2mTBSFwY3p-TDcEUuGtslvP7bNfnYbd83T9n-5fF5c7_PHC_FlBWNQm1KhVApYStnrANV1Aw0YA2FRMk4Byc1grPCcdWgKTUIVZWiKI0Ta3L76x3nqsf6MEZ_Cj8e_g-KH8fiU7s |
ContentType | Journal Article |
DBID | NPM |
DOI | 10.3171/2024.2.PEDS23551 |
DatabaseName | PubMed |
DatabaseTitle | PubMed |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
EISSN | 1933-0715 |
ExternalDocumentID | 38457794 |
Genre | Journal Article |
GroupedDBID | --- 0R~ 53G 5GY 5RE AAQQT AAWTL ABIMC ABOCM AFOSN ALMA_UNASSIGNED_HOLDINGS CS3 EBS EJD EMOBN F5P HZ~ L7B NEU NPM O9- SJN TR2 |
ID | FETCH-LOGICAL-c182t-6f5e7985e3b52abc9ac356d0373ed364e40113c47e3ca2c15fe987325b82689c2 |
IngestDate | Sat Nov 02 12:30:48 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | trauma postconcussion symptoms blood biomarkers pediatric concussion mild traumatic brain injury posttraumatic headache |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c182t-6f5e7985e3b52abc9ac356d0373ed364e40113c47e3ca2c15fe987325b82689c2 |
PMID | 38457794 |
ParticipantIDs | pubmed_primary_38457794 |
PublicationCentury | 2000 |
PublicationDate | 2024-06-01 |
PublicationDateYYYYMMDD | 2024-06-01 |
PublicationDate_xml | – month: 06 year: 2024 text: 2024-06-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Journal of neurosurgery. Pediatrics |
PublicationTitleAlternate | J Neurosurg Pediatr |
PublicationYear | 2024 |
SSID | ssj0042491 |
Score | 2.3987718 |
Snippet | Posttraumatic headache (PTH) represents the most common acute and persistent symptom in children after concussion, yet there is no blood protein signature to... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 1 |
Title | Capillary blood protein markers of posttraumatic headache in children after concussion |
URI | https://www.ncbi.nlm.nih.gov/pubmed/38457794 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS8MwEA9OQfYiit9f5MG30to2ST8eZW4MwSH4gW-SpCkIrhuzQ9xf7yVpVx1O1JdSmrSE3O-ud5f7QOgs0EdLmSDAacR3aaYYyEHOXf0rIZSK2DfNJq4HUf-eXj2yx-YoxmSXlMKTs2_zSv5DVXgGdNVZsn-g7Pyj8ADugb5wBQrD9Vc07vCxbho0ebfx544puvBcOEMdczMxQRrj0WtZTvjUVmYFyZvpCs7ayzFP47ZtwsEullMdElss0Vdt5UubRe058xYfTf6IdaX2lJafjYNUvNT68azJerh941WUWRfW73QbZ2sfOM-eTVTxZ85V5citXBMhbUKoPGXFaUqITpFin0Rk8J3gBi3G5KbAR7zQu-le3oagCH2ZCls_HhpCkoSyOLa9kX8eXSilXQ-1UCtOdJ-PgXbt2N82BTs0sOfYejHni0tpo_X69QULxGgid5tooyIJvrB42EIrqthGD3MsYIMFXGEBV1jAoxx_wQKusYBhUo0FbLCAGyzsoPte967Td6ueGa4EtivdKGcqThOmiGAhFzLlkrAo80lMVEYiqsCeDoiksSKShzLQsYbApiETYGcmqQx30WoxKtQ-wn7KSR5GStE8oxHjKZPCV1FOopinScAO0J7dhqexLYzyVG_Q4dKRI9RugHKM1nLgRHUCal0pTg05PgClzE1a |
link.rule.ids | 780 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Capillary+blood+protein+markers+of+posttraumatic+headache+in+children+after+concussion&rft.jtitle=Journal+of+neurosurgery.+Pediatrics&rft.au=Fan%2C+Feiven&rft.au=Babl%2C+Franz+E&rft.au=Swaney%2C+Ella+E+K&rft.au=Hearps%2C+Stephen+J+C&rft.date=2024-06-01&rft.eissn=1933-0715&rft.spage=1&rft_id=info:doi/10.3171%2F2024.2.PEDS23551&rft_id=info%3Apmid%2F38457794&rft_id=info%3Apmid%2F38457794&rft.externalDocID=38457794 |