A CO 2 sensing module modulates β-1,3-glucan exposure in Candida albicans

• Published in: mBio Vol. 15; no. 2; p. e0189823
• Main Authors: Avelar, Gabriela M, Pradhan, Arnab, Ma, Qinxi, Hickey, Emer, Leaves, Ian, Liddle, Corin, Rodriguez Rondon, Alejandra V, Kaune, Ann-Kristin, Shaw, Sophie, Maufrais, Corinne, Sertour, Natacha, Bain, Judith M, Larcombe, Daniel E, de Assis, Leandro J, Netea, Mihai G, Munro, Carol A, Childers, Delma S, Erwig, Lars P, Brown, Gordon D, Gow, Neil A R, Bougnoux, Marie-Elisabeth, d'Enfert, Christophe, Brown, Alistair J P
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 14.02.2024
• Subjects: beta-Glucans; Candida albicans - metabolism; Carbon Dioxide - metabolism; Cell Wall - metabolism; Glucans - metabolism; Humans; Hypoxia - metabolism; Lactates - metabolism; Life Sciences; Pathogen-Associated Molecular Pattern Molecules; Candida albicans; β-glucan masking; carbonic anhydrase; pathogen-associated molecular patterns; immune evasion; NCE103

Microbial species capable of co-existing with healthy individuals, such as the commensal fungus exploit multifarious strategies to evade our immune defenses. These strategies include the masking of immunoinflammatory pathogen-associated molecular patterns (PAMPs) at their cell surface. We reported p...