Simultaneous suppression of MITF and BRAF V600E enhanced inhibition of melanoma cell proliferation

• Published in: Cancer science Vol. 100; no. 10; pp. 1863 - 1869
• Main Authors: Kido, Kenji, Sumimoto, Hidetoshi, Asada, Sakiyo, Okada, Starlyn M, Yaguchi, Tomonori, Kawamura, Naoshi, Miyagishi, Makoto, Saida, Toshiaki, Kawakami, Yutaka
• Format: Journal Article
• Language: English
• Published: England 01.10.2009
• Subjects: Blotting, Western; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Melanoma - genetics; Melanoma - metabolism; Microphthalmia-Associated Transcription Factor - genetics; Microphthalmia-Associated Transcription Factor - metabolism; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins B-raf - genetics; Proto-Oncogene Proteins B-raf - metabolism; Signal Transduction - physiology

Microphthalmia-associated transcription factor (MITF) is a master gene regulating differentiation of melanocytes, and a lineage survival oncogene mediating pro-proliferative function in malignant melanoma. However, high expression of MITF also has an anti-proliferative effect. To clarify the therape...