The plakortones, novel bicyclic lactones from the sponge Plakortis halichondrioides: Activators of cardiac SR-Ca2+-pumping ATPase

• Published in: Tetrahedron Vol. 52; no. 2; pp. 377 - 394
• Main Authors: Patil, AD, Freyer, AJ, Bean, MF, Carte, BK, Westley, JW, Johnson, RK, Lahouratate, P
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier 08.01.1996
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; METABOLITES; ACIDS; ANGULOSPICULATUS; LITA; CYCLIC PEROXIDES; SARCOPLASMIC-RETICULUM; MARINE SPONGE

Bioassay-guided fractionation of the EtOAc extract of sponge Plakortis halichondroides yielded four novel bicyclic lactones, plakortones A, B, C, D and a novel acid, plakortide E (3, 4, 5, 6 and 7). The structures, including stereochemistry, of these compounds were established by interpretation of s...