Trombosis de senos venosos cerebrales en una niña con leucemia linfoblástica, portadora de la variante de la protrombina G20210A
Resumen Aunque la trombosis de senos venosos cerebrales es rara, se asocia con mayor frecuencia en niños con leucemia linfoblástica aguda. Se aporta el caso de una niña de 7 años que desarrolla una trombosis masiva de senos venosos cerebrales en el día 22 del tratamiento de inducción de leucemia lin...
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| Published in | Anales de pediatría (Barcelona, Spain : 2003) Vol. 78; no. 4; pp. 263 - 267 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Spanish |
| Published |
Elsevier Espana
01.04.2013
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| Subjects | |
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| Abstract | Resumen Aunque la trombosis de senos venosos cerebrales es rara, se asocia con mayor frecuencia en niños con leucemia linfoblástica aguda. Se aporta el caso de una niña de 7 años que desarrolla una trombosis masiva de senos venosos cerebrales en el día 22 del tratamiento de inducción de leucemia linfoblástica aguda de alto riesgo. Clínicamente se manifestaron de forma progresiva cefalea, disminución del nivel de conciencia y hemiplejía izquierda. El estudio de trombofilia posterior reveló heterocigosis para la variante de la protrombina G20210A en la niña y en la madre. Se analizan los factores protrombóticos encontrados en el caso antes y después de la trombosis. Se confirma la importancia de investigar precozmente tanto los factores de riesgo de trombosis adquiridos como los estados de trombofilia primaria en niños con leucemia linfoblástica. Esta estrategia podría ayudar a identificar a pacientes de especial riesgo e instaurar en ellos tromboprofilaxis. |
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| AbstractList | Resumen Aunque la trombosis de senos venosos cerebrales es rara, se asocia con mayor frecuencia en niños con leucemia linfoblástica aguda. Se aporta el caso de una niña de 7 años que desarrolla una trombosis masiva de senos venosos cerebrales en el día 22 del tratamiento de inducción de leucemia linfoblástica aguda de alto riesgo. Clínicamente se manifestaron de forma progresiva cefalea, disminución del nivel de conciencia y hemiplejía izquierda. El estudio de trombofilia posterior reveló heterocigosis para la variante de la protrombina G20210A en la niña y en la madre. Se analizan los factores protrombóticos encontrados en el caso antes y después de la trombosis. Se confirma la importancia de investigar precozmente tanto los factores de riesgo de trombosis adquiridos como los estados de trombofilia primaria en niños con leucemia linfoblástica. Esta estrategia podría ayudar a identificar a pacientes de especial riesgo e instaurar en ellos tromboprofilaxis. Aunque la trombosis de senos venosos cerebrales es rara, se asocia con mayor frecuencia en niños con leucemia linfoblástica aguda. Se aporta el caso de una niña de 7 años que desarrolla una trombosis masiva de senos venosos cerebrales en el día 22 del tratamiento de inducción de leucemia linfoblástica aguda de alto riesgo. Clínicamente se manifestaron de forma progresiva cefalea, disminución del nivel de conciencia y hemiplejía izquierda. El estudio de trombofilia posterior reveló heterocigosis para la variante de la protrombina G20210A en la niña y en la madre. Se analizan los factores protrombóticos encontrados en el caso antes y después de la trombosis. Se confirma la importancia de investigar precozmente tanto los factores de riesgo de trombosis adquiridos como los estados de trombofilia primaria en niños con leucemia linfoblástica. Esta estrategia podría ayudar a identificar a pacientes de especial riesgo e instaurar en ellos tromboprofilaxis. Although cerebral venous thrombosis is rare, it is more commonly associated with children suffering from acute lymphoblastic leukaemia. We report the case of a 7-year-old girl who developed massive cerebral sinovenous thrombosis on day 22 of induction therapy for high-risk acute lymphoblastic leukaemia. Clinical symptoms were gradual onset of headache, decreasing consciousness, and ensuing left hemiplegia. A subsequent prothrombotic study revealed a heterozygous prothrombin G20210A variant in the child and mother. We analysed the prothrombotic factors found in the case before and after thrombosis. We confirm the importance of early exploration of patients for clinical predisposing risk factors of thrombosis and primary prothrombotic states in children with acute lymphoblastic leukaemia. This might help identify patients at particular risk from thrombosis and so administer thromboprophylaxis. |
| Author | Sacoto Erazo, G Álvarez Guisasola, F.J Fernández Abril, M.C Blanco Quirós, A González García, H Moreno Gómez, E |
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| Cites_doi | 10.1016/j.thromres.2003.10.013 10.1016/j.thromres.2003.10.007 10.1182/blood-2006-04-015511 10.1097/00001721-200107000-00005 10.1055/s-0037-1613930 10.1007/PL00014341 10.1182/blood-2009-07-231084 10.1002/ajh.21665 10.1002/cncr.11042 10.1111/j.1365-2141.2007.06677.x 10.1182/blood.V83.5.1251.1251 10.1160/TH02-11-0283 10.1182/blood-2002-06-1901 10.1097/00043426-200306000-00011 10.1016/j.thromres.2003.10.008 10.1111/j.1365-2141.2005.05528.x 10.1182/blood.V93.5.1595 |
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| DocumentTitleAlternate | Cerebral sinovenous thrombosis in a girl with acute lymphoblastic leukaemia carrying the prothrombin G20210A variant |
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| Keywords | Variante de la protrombina G20210A Leucemia linfoblástica aguda Thrombophilic genetic abnormalities Cerebral sinovenous thrombosis Prothrombin G20210A variant Trombosis cerebral Cerebral thrombosis Catéter venoso central Asparraginasa Trombosis de senos venosos cerebrales Central venous catheter Acute lymphoblastic leukaemia Trombofilia primaria Asparaginase |
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Results of the PAARKA study publication-title: Thromb Haemost doi: 10.1160/TH02-11-0283 contributor: fullname: Mitchell – volume: 101 start-page: 2529 year: 2003 ident: 10.1016/j.anpedi.2012.08.004_bib0065 article-title: Thromboembolic events in children with acute lymphoblastic leukemia (BFM protocols): prednisone versus dexamethasone administration publication-title: Blood doi: 10.1182/blood-2002-06-1901 contributor: fullname: Nowak-Göttl – volume: 25 start-page: 484 year: 2003 ident: 10.1016/j.anpedi.2012.08.004_bib0035 article-title: Cerebrovascular complications of L-asparaginase in the therapy of acute lymphoblastic leukemia publication-title: J Pediatr Hematol Oncol doi: 10.1097/00043426-200306000-00011 contributor: fullname: Kieslich – volume: 111 start-page: 321 year: 2003 ident: 10.1016/j.anpedi.2012.08.004_bib0040 article-title: Thrombosis in children with acute lymphoblastic leukemia. Part III. Pathogenesis of thrombosis in children with acute lymphoblastic leukemia: effects of host environment publication-title: Thromb Res doi: 10.1016/j.thromres.2003.10.008 contributor: fullname: Athale – volume: 129 start-page: 803 year: 2005 ident: 10.1016/j.anpedi.2012.08.004_bib0055 article-title: Thromboembolism in children with acute lymphoblastic leukaemia treated on Dana-Farber Cancer Institute protocols: effect of age and risk stratification of disease publication-title: Br J Haematol doi: 10.1111/j.1365-2141.2005.05528.x contributor: fullname: Athale – volume: 93 start-page: 1595 year: 1999 ident: 10.1016/j.anpedi.2012.08.004_bib0080 article-title: Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors publication-title: Blood doi: 10.1182/blood.V93.5.1595 contributor: fullname: Nowak-Göttl |
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| Snippet | Resumen Aunque la trombosis de senos venosos cerebrales es rara, se asocia con mayor frecuencia en niños con leucemia linfoblástica aguda. Se aporta el caso de... Aunque la trombosis de senos venosos cerebrales es rara, se asocia con mayor frecuencia en niños con leucemia linfoblástica aguda. Se aporta el caso de una... |
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| SubjectTerms | Acute lymphoblastic leukaemia Asparaginase Asparraginasa Catéter venoso central Central venous catheter Cerebral sinovenous thrombosis Cerebral thrombosis Leucemia linfoblástica aguda Pediatrics Prothrombin G20210A variant Thrombophilic genetic abnormalities Trombofilia primaria Trombosis cerebral Trombosis de senos venosos cerebrales Variante de la protrombina G20210A |
| Title | Trombosis de senos venosos cerebrales en una niña con leucemia linfoblástica, portadora de la variante de la protrombina G20210A |
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