CLINICOPATHOLOGICAL FACTORS AND LONG-TERM PROGNOSIS IN PATIENTS WITH OBSTRUCTING COLORECTAL CANCER

• Published in: Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) Vol. 59; no. 9; pp. 2223 - 2229
• Main Authors: KIDOGAWA, Hideo, ITO, Shigehiko, NAKATANI, Hiroyuki, KASHIMA, Kiyotaka, IDE, Seiichiro, NAKAMURA, Akihiro, KOBAYASHI, Masahiro, YOSHIDA, Kazuya, KAJIWARA, Keiji, OHE, Hisakuni
• Format: Journal Article
• Language: English
• Published: Japan Surgical Association 25.09.1998
• DOI: 10.3919/jjsa.59.2223
• ISSN: 1345-2843

We studied obstructing colorectal cancer by comparing with those without obstruction to elucidate the long-term prognosis. Subject were 357 patients with colorectal cancer including 79 (21.1%) patients who manifested ileus symptoms initially (obstructed group) and another 278 (79.9%) patients without ileus symptoms (not obstructed group). In this study, we designated the patients with ileus symptoms as those who developed abdominal pain, vomiting, and abdominal distention, had air-fluid level formation in an abdominal simple X-ray film on standing position, and needed some decompression treatment. The obstructing group was comprized of more aged patients and the lesion was frequently found in the descending colon. And more cases with deeper depth of invasion of tumor and metastasis due to peritoneal dissemination were seen in the obstructing group. There were, however, no significant differences between both groups in tumor type, lymph node metastasis, hepatic metastasis, vascular invasion, lynphatic invasion, histologic type, and degree of progress. Overall survival rate was significantly poorer in the obstructing group than that in the other, but no significant difference in the survival rate was noted when curatively resected cases from both groups were compared. According to multivariate analysis, determinant prognostic factors of colorectal cancer were curability, sex, lymph node metastasis, and invasion depth of tumor.