COVID-19 extracellular vesicles display heterogeneity based on viral and host RNA expression: implications for host immune response

• Published in: Journal of leukocyte biology Vol. 117; no. 2
• Main Authors: Juárez, Esmeralda, Vázquez-Pérez, Joel A, Carreto-Binaghi, Laura E, Martínez-Sanabria, Claudia A, Salgado-Cantú, Manuel G, Sarabia, Carmen, Herrera, María Teresa, Guzmán-Beltrán, Silvia, Gutiérrez-González, Luis H, González, Yolanda
• Format: Journal Article
• Language: English
• Published: England 13.02.2025
• Subjects: Adult; COVID-19 - genetics; COVID-19 - immunology; COVID-19 - virology; Cytokines; Extracellular Vesicles - genetics; Extracellular Vesicles - immunology; Extracellular Vesicles - metabolism; Female; Humans; Lipopolysaccharides - pharmacology; Male; MicroRNAs - genetics; MicroRNAs - immunology; Middle Aged; RNA, Viral - genetics; RNA, Viral - immunology; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; SARS-CoV2; cytokines; EVs; miRNAs; inflammation

Viral RNA and miRNAs released by immune cells contribute to inflammation in COVID-19 patients. Here, we investigated the role of SARS-CoV2 RNA and host miRNAs carried within extracellular vesicles (EVs) in modulating inflammation. EVs were classified as positive or negative depending on their viral...