Improving D-2-hydroxyglutarate MR spectroscopic imaging in mutant isocitrate dehydrogenase glioma patients with multiplexed RF-receive/B 0 -shim array coils at 3 T

• Published in: NMR in biomedicine Vol. 35; no. 1; p. e4621
• Main Authors: Strasser, Bernhard, Arango, Nicolas S, Stockmann, Jason P, Gagoski, Borjan, Thapa, Bijaya, Li, Xianqi, Bogner, Wolfgang, Moser, Philipp, Small, Julia, Cahill, Daniel P, Batchelor, Tracy T, Dietrich, Jorg, van der Kouwe, Andre, White, Jacob, Adalsteinsson, Elfar, Andronesi, Ovidiu C
• Format: Journal Article
• Language: English
• Published: England 01.01.2022
• Subjects: Adult; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - metabolism; Female; Glioma - diagnostic imaging; Glioma - metabolism; Glutarates - analysis; Humans; Isocitrate Dehydrogenase - genetics; Isocitrate Dehydrogenase - physiology; Magnetic Resonance Imaging - methods; Male; Mutation; precision oncology; glioma brain tumor; magnetic resonance spectroscopic imaging; multicoil shimming; isocitrate dehydrogenase mutations; D-2-hydroxyglutarate; multiplexed RF-receive and B0-shim array
• ISSN: 0952-3480; 1099-1492
• DOI: 10.1002/nbm.4621

MR spectroscopic imaging (MRSI) noninvasively maps the metabolism of human brains. In particular, the imaging of D-2-hydroxyglutarate (2HG) produced by glioma isocitrate dehydrogenase (IDH) mutations has become a key application in neuro-oncology. However, the performance of full field-of-view MRSI is limited by B spatial nonuniformity and lipid artifacts from tissues surrounding the brain. Array coils that multiplex RF-receive and B -shim electrical currents (AC/DC mixing) over the same conductive loops provide many degrees of freedom to improve B uniformity and reduce lipid artifacts. AC/DC coils are highly efficient due to compact design, requiring low shim currents (<2 A) that can be switched fast (0.5 ms) with high interscan reproducibility (10% coefficient of variation for repeat measurements). We measured four tumor patients and five volunteers at 3 T and show that using AC/DC coils in addition to the vendor-provided second-order spherical harmonics shim provides 19% narrower spectral linewidth, 6% higher SNR, and 23% less lipid content for unrestricted field-of-view MRSI, compared with the vendor-provided shim alone. We demonstrate that improvement in MRSI data quality led to 2HG maps with higher contrast-to-noise ratio for tumors that coincide better with the FLAIR-enhancing lesions in mutant IDH glioma patients. Smaller Cramér-Rao lower bounds for 2HG quantification are obtained in tumors by AC/DC shim, corroborating with simulations that predicted improved accuracy and precision for narrower linewidths. AC/DC coils can be used synergistically with optimized acquisition schemes to improve metabolic imaging for precision oncology of glioma patients. Furthermore, this methodology has broad applicability to other neurological disorders and neuroscience.