Study on the targets and mechanisms of 7-hydroxyethyl chrysin in prevention and treatment of high-altitude cerebral edema using proteomics technology

• Published in: Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban Vol. 54; no. 4; pp. 549 - 558
• Main Authors: ZHANG, Dongmei, LI, Xiaolin, YANG, Chenyu, JING, Linlin, HE, Lei, MA, Huiping
• Format: Journal Article
• Language: Chinese
• Published: China 21.07.2025
• Subjects: Altitude Sickness - drug therapy; Altitude Sickness - metabolism; Altitude Sickness - prevention & control; Animals; Brain Edema - drug therapy; Brain Edema - etiology; Brain Edema - metabolism; Brain Edema - prevention & control; Flavonoids - pharmacology; Flavonoids - therapeutic use; Male; Protein Interaction Maps; Proteomics - methods; Rats; Rats, Wistar; 7-Hydroxyethyl chrysin; High-altitude cerebral edema; Proteomics; Rats; Tandem mass tags; Bioinformatics; Differentially expressed proteins

To investigate the targets and mechanisms of 7-hydroxyethyl chrysin (7-HEC) in prevention and treatment of high-altitude cerebral edema (HACE) in rats. Fifty-four male Wistar rats were randomly divided into normal control group, HACE model group, and 7-HEC-treated group (18 rats in each group). Exce...