1,25-Dihydroxyvitamin D 3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-κB pathway

• Published in: American journal of physiology. Renal physiology Vol. 296; no. 5; pp. F1212 - F1218
• Main Authors: Deb, Dilip K., Chen, Yunzi, Zhang, Zhongyi, Zhang, Yan, Szeto, Frances L., Wong, Kari E., Kong, Juan, Li, Yan Chun
• Format: Journal Article
• Language: English
• Published: 01.05.2009

The renin-angiotensin system (RAS) is a major mediator of renal injury in diabetic nephropathy. Our previous studies demonstrated that 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] plays a renoprotective role by suppressing the RAS, with renin and angiotensinogen (AGT) as the main targets. The mechani...