Metformin Enhances Doxycycline Efficacy Against Pasteurella multocida: Evidence from In Vitro, In Vivo, and Morphological Studies

• Published in: Microorganisms (Basel) Vol. 13; no. 8; p. 1724
• Main Authors: Jiang, Nansong, Wang, Weiwei, Liang, Qizhang, Fu, Qiuling, Liu, Rongchang, Fu, Guanghua, Wan, Chunhe, Cheng, Longfei, Huang, Yu, Chen, Hongmei
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 23.07.2025; MDPI
• Subjects: Adjuvants; Animal health; Antibacterial activity; Antibiotics; Antimicrobial agents; Aquatic birds; Avian cells; Biocompatibility; Cytotoxicity; Diabetes mellitus; Doxycycline; Drug resistance; Economic impact; Effectiveness; Efflux; In vivo methods and tests; Infections; Intracellular; Membrane permeability; Membrane potential; Membranes; Metformin; Pasteurella multocida; Pathogens; Poultry; Surveillance; Tetracyclines; Toxicity; Veterinary medicine; Beijing China; United States > US; China

Pasteurella multocida (Pm) is a zoonotic pathogen that poses a significant threat to animal health and causes substantial economic losses, further aggravated by rising tetracycline resistance. To restore the efficacy of tetracyclines to Pm, we evaluated the synergistic antibacterial activity of doxy...