Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cell LNCaP

• Published in: Acta pharmacologica Sinica Vol. 28; no. 3; pp. 423 - 430
• Main Authors: Zhang, Hui-Na, Yu, Chun-Xiao, Zhang, Peng-Ju, Chen, Wei-Wen, Jiang, An-Li, Kong, Feng, Deng, Jing-Ti, Zhang, Jian-Ye, Young, Charles Yf
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.03.2007
• Subjects: Androgens - pharmacology; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Curcumin - pharmacology; Down-Regulation - drug effects; Homeodomain Proteins - biosynthesis; Homeodomain Proteins - genetics; Humans; Male; Metribolone - pharmacology; NKX3.1; Prostatic Neoplasms - metabolism; Receptors, Androgen - biosynthesis; Receptors, Androgen - genetics; Transcription Factors - biosynthesis; Transcription Factors - genetics; Transfection; 减量调节; 前列腺癌细胞; 同源框基因; 姜黄色素; 雄激素受体

Aim： To elucidate the effect and the mechanisms of curcumin on the expression of the human homeobox gene NKX3.1 in the prostate cancer cell LNCaP. Methods： The expression change of NKX3.1 in cells incubated with varying concentrations of curcumin was observed by Western blotting and RT-PCR. A dual l...