CYP2D6 polymorphism screening in a selected population of Spain (La Alpujarra): No effect of geographical isolation

• Published in: Annals of human biology Vol. 37; no. 2; pp. 1 - 7
• Main Authors: Fernandez-Santander, Ana, Luna, Francisco, Santiago, Catalina, Rodriguez, Maria Teresa, Bandres, Fernando, Ruiz, Jonatan, Lucia, Alejandro, Gomez-Gallego, Felix
• Format: Journal Article
• Language: English
• Published: England 01.04.2010
• Subjects: Adult; Aged; Aged, 80 and over; Cohort Studies; Cytochrome P-450 CYP2D6 - genetics; Female; Gene Frequency; Genetic Testing; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Spain; Spain

There is growing interest in the CYP2D6 gene because of its key role in the metabolism of numerous commonly used drugs. We compared the frequency of the most frequent null CYP2D6 alleles (CYP2D6*3, CYP2D6*4,CYP2D6*5, CYP2D6*6, CYP2D6*7 and CYP2D6*8) between individuals from the Spanish population an...