Color Change of Various Medicines under LED Lighting and Fluorescent Lighting

Light emitting diodes (LEDs) are widely used in lighting applications. In this study, we examined the differences in the degree of the color change of various medicines between LED lighting and fluorescent lighting. The degree of the color change of the medicines was evaluated subjectively, by the o...

Full description

Saved in:
Bibliographic Details
Published inIryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Vol. 41; no. 3; pp. 198 - 204
Main Authors Yamashita, Shuji, Noguchi, Yoshihiro, Kubota, Masafumi, Iguchi, Kazuhiro, Aoki, Shinya, Tanei, Shigeharu, Nakamura, Mitsuhiro, Teramachi, Hitomi, Sugiyama, Tadashi
Format Journal Article
LanguageEnglish
Published Japanese Society of Pharmaceutical Health Care and Sciences 10.03.2015
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Light emitting diodes (LEDs) are widely used in lighting applications. In this study, we examined the differences in the degree of the color change of various medicines between LED lighting and fluorescent lighting. The degree of the color change of the medicines was evaluated subjectively, by the observation of the evaluator, as well as objectively, using a colorimeter. Noticeable color changes were observed in the Lasix® 20-mg Tablet(Tab), Fluitran® 2-mg Tab, and Phenobal® powder after exposure to either LED lighting or fluorescent lighting. Interestingly, the color change of the Lasix® 20-mg Tab was smaller for the LED lighting than for the fluorescent lighting.
AbstractList Light emitting diodes (LEDs) are widely used in lighting applications. In this study, we examined the differences in the degree of the color change of various medicines between LED lighting and fluorescent lighting. The degree of the color change of the medicines was evaluated subjectively, by the observation of the evaluator, as well as objectively, using a colorimeter. Noticeable color changes were observed in the Lasix® 20-mg Tablet(Tab), Fluitran® 2-mg Tab, and Phenobal® powder after exposure to either LED lighting or fluorescent lighting. Interestingly, the color change of the Lasix® 20-mg Tab was smaller for the LED lighting than for the fluorescent lighting.
Author Yamashita, Shuji
Sugiyama, Tadashi
Aoki, Shinya
Nakamura, Mitsuhiro
Iguchi, Kazuhiro
Noguchi, Yoshihiro
Tanei, Shigeharu
Kubota, Masafumi
Teramachi, Hitomi
Author_xml – sequence: 1
  fullname: Yamashita, Shuji
  organization: Gifu Pharmaceutical University Pharmacy
– sequence: 2
  fullname: Noguchi, Yoshihiro
  organization: Gifu Pharmaceutical University Pharmacy
– sequence: 3
  fullname: Kubota, Masafumi
  organization: Gifu Pharmaceutical University Pharmacy
– sequence: 4
  fullname: Iguchi, Kazuhiro
  organization: Gifu Pharmaceutical University Pharmacy
– sequence: 5
  fullname: Aoki, Shinya
  organization: Gifu Pharmaceutical University Pharmacy
– sequence: 6
  fullname: Tanei, Shigeharu
  organization: Gifu Pharmaceutical University Pharmacy
– sequence: 7
  fullname: Nakamura, Mitsuhiro
  organization: Gifu Pharmaceutical University Pharmacy
– sequence: 8
  fullname: Teramachi, Hitomi
  organization: Gifu Pharmaceutical University Pharmacy
– sequence: 9
  fullname: Sugiyama, Tadashi
  organization: Gifu Pharmaceutical University Pharmacy
BookMark eNpNkL1OwzAYRS1UJErpyO4XSPF_7A0Uyo-UigUQm-U4duIqOJWdDrw9Ra0qpvtJ93x3ONdgFsfoALjFaMUFU3fb7a63ecXwCit5AeZYSlJgptTscFMmCsrI1xVY5hwahLhCBHMxB5tqHMYEq97EzsHRw0-TwrjPcOPaYEN0Ge5j6xKs14-wDl0_hdhBE1v4NOzH5LJ1cToXN-DSmyG75SkX4ONp_V69FPXb82v1UBcWl1IWHLVUGiMMN9bIklhCpfctLkuOFWbek4YyLprWC6SEtc6WTpUEN1ZJY7GiC1Acd20ac07O610K3yb9aIz0nw591KEZ1gcdB_7-yG_zZDp3pk2agh3cP5qeXs6V7U3SLtJfbPRt9A
CitedBy_id crossref_primary_10_5649_jjphcs_44_83
crossref_primary_10_5649_jjphcs_46_222
crossref_primary_10_1186_s40780_018_0108_0
crossref_primary_10_15583_jpchrom_2021_015
crossref_primary_10_3390_pharmaceutics15020697
crossref_primary_10_5649_jjphcs_42_512
crossref_primary_10_15583_jpchrom_2022_021
Cites_doi 10.1002/jps.10575
10.1111/j.2042-7158.1994.tb03770.x
10.1016/0378-5173(89)90098-7
10.1248/yakushi1947.101.12_1149
10.11468/seikatsueisei1957.34.23
10.5649/jjphcs.35.395
10.1248/yakushi1947.100.9_953
10.1248/yakushi1947.108.12_1203
10.5649/jjphcs1975.11.276
ContentType Journal Article
Copyright 2015 Japanese Society of Pharmaceutical Health Care and Sciences
Copyright_xml – notice: 2015 Japanese Society of Pharmaceutical Health Care and Sciences
DBID AAYXX
CITATION
DOI 10.5649/jjphcs.41.198
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Pharmacy, Therapeutics, & Pharmacology
EISSN 1882-1499
EndPage 204
ExternalDocumentID 10_5649_jjphcs_41_198
article_jjphcs_41_3_41_198_article_char_en
GroupedDBID .LE
5GY
ALMA_UNASSIGNED_HOLDINGS
JSF
KQ8
MOJWN
RJT
AAYXX
ABJNI
CITATION
ID FETCH-LOGICAL-c1788-50d38aa6a5aca872c238ffd17751914ff2b3456bdf6096ccec7e9721bc98ac193
ISSN 1346-342X
IngestDate Fri Aug 23 01:01:43 EDT 2024
Wed Apr 05 04:38:57 EDT 2023
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed false
IsScholarly true
Issue 3
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c1788-50d38aa6a5aca872c238ffd17751914ff2b3456bdf6096ccec7e9721bc98ac193
OpenAccessLink https://www.jstage.jst.go.jp/article/jjphcs/41/3/41_198/_article/-char/en
PageCount 7
ParticipantIDs crossref_primary_10_5649_jjphcs_41_198
jstage_primary_article_jjphcs_41_3_41_198_article_char_en
PublicationCentury 2000
PublicationDate 2015/03/10
PublicationDateYYYYMMDD 2015-03-10
PublicationDate_xml – month: 03
  year: 2015
  text: 2015/03/10
  day: 10
PublicationDecade 2010
PublicationTitle Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
PublicationTitleAlternate Jpn. J. Pharm. Health Care Sci.
PublicationYear 2015
Publisher Japanese Society of Pharmaceutical Health Care and Sciences
Publisher_xml – name: Japanese Society of Pharmaceutical Health Care and Sciences
References 4)平成9年5月28日, 薬審第422号, 新原薬及び新製剤の光安定性試験ガイドラインについて(厚生省薬務局審査課長通知
15)澤田康文, 過誤防止ノート ヒヤリハット事例に学ぶ 薬の味や色が変わり服用中止, 日経ドラッグインフォメーション, 2007, 121, 42-44.
13)久道周彦, 高橋將喜, 一包化調剤の留意点-患者保管時における光安定性-, 日本薬剤師会雑誌, 2000, 52, 683-692
12)久道周彦, 鎌田佐知子, 白取美幸, 後藤希久子, 菊地宏明, 中村郁子, 高橋將喜, アズレン・グルタミンの安定性について-患者保管想定時における安定性試験-, 医学と薬学, 1998, 40, 869-876.
3) Matsuda Y, Teraoka R, Sugimoto I, Comparative evaluation of photostability of solid-state nifedipine under ordinary and intensive light irradiation conditions, Int J Pharm, 1989, 54, 211-221.
1) Kakinoki K, Yamane K, Teraoka R, Otsuka M, Matsuda Y, Effect of relative humidity on the photocatalytic activity of titanium dioxide and photostability of famotidine, J Pharm Sci, 2004, 93, 582-589.
7)杉本 功, 東郷和紀, 佐々木広三, 中川 寛, 松田芳久, 昌原麗子, ニフェジピン錠の光分解におよぼす波長依存性, 薬学雑誌, 1981, 101, 1149-1153.
9)LED照明推進協議会編, “LED照明ハンドブック(改訂版)”, オーム社, 東京, 2011, pp36-38.
14)上野芳男, 田中恵子, 近藤由利子, コンプライアンスに影響を与える要因, 病院薬学, 1985, 11, 276-283.
11)清水弘明, 林田 滋, 我妻永利, 医薬品の分解とその安定化(第21報)グアイアズレンスルホン酸ナトリウムの光分解反応とその安定化, 薬学雑誌, 1988, 108, 1203-1208.
6)寺岡麗子, 横山郁子, 杉本 功, 牛尾真奈美, 北河修治, フロセミド錠の光安定性に及ぼす着色PTP包装材料の影響, 医療薬学, 2009, 35, 395-402.
10)梅澤智佐江, 尾崎俊江, 吉崎博美, 新真理子, 細野恭平, 守安雅代, 藤井正美, 赤色系着色添加物の耐光性能, 生活衛生, 1990, 34, 23-35.
2) Matsuda Y, Akazawa R, Teraoka R, Otsuka M, Pharmaceutical evaluation of carbamazepine modifications: comparative study for photostability of carbamazepine polymorphs by using fourier-transformed reflection-absorption infrared spectroscopy and colorimetric measurement, J Pharm Pharmacol, 1994, 46, 162-167.
8)松田芳久, 昌原麗子, 数種の光源下における固形医薬品の着色に関する比較評価, 薬学雑誌, 1980, 100, 953-957.
5)久道周彦, 後藤希久子, 白取美幸, 鎌田佐知子, 菊地宏明, 高橋將喜, 一包化調剤の落とし穴-患者保管想定時における薬剤安定性試験の必要性-, 医薬ジャーナル, 1999, 35, 175-178.
1
2
3
4
(6) 1980; 100
7
9
(5) 1981; 101
(8) 1988; 108
References_xml – ident: 1
  doi: 10.1002/jps.10575
– ident: 2
  doi: 10.1111/j.2042-7158.1994.tb03770.x
– ident: 3
  doi: 10.1016/0378-5173(89)90098-7
– volume: 101
  start-page: 1149
  issn: 0031-6903
  year: 1981
  ident: 5
  publication-title: YAKUGAKU ZASSHI
  doi: 10.1248/yakushi1947.101.12_1149
– ident: 7
  doi: 10.11468/seikatsueisei1957.34.23
– ident: 4
  doi: 10.5649/jjphcs.35.395
– volume: 100
  start-page: 953
  issn: 0031-6903
  year: 1980
  ident: 6
  publication-title: YAKUGAKU ZASSHI
  doi: 10.1248/yakushi1947.100.9_953
– volume: 108
  start-page: 1203
  issn: 0031-6903
  year: 1988
  ident: 8
  publication-title: YAKUGAKU ZASSHI
  doi: 10.1248/yakushi1947.108.12_1203
– ident: 9
  doi: 10.5649/jjphcs1975.11.276
SSID ssib005902156
ssib003116159
ssib002484604
ssib000871962
ssib023157658
ssj0069027
Score 1.9512454
Snippet Light emitting diodes (LEDs) are widely used in lighting applications. In this study, we examined the differences in the degree of the color change of various...
SourceID crossref
jstage
SourceType Aggregation Database
Publisher
StartPage 198
SubjectTerms color change
compliance
fluorescent lighting
LED lighting
medicine
Title Color Change of Various Medicines under LED Lighting and Fluorescent Lighting
URI https://www.jstage.jst.go.jp/article/jjphcs/41/3/41_198/_article/-char/en
Volume 41
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 2015/03/10, Vol.41(3), pp.198-204
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLfK4MAF8SnGl3xAvWwpTeIkzRHBpo1RNESHdotsJ1lXWD2ljVD31_PzR91s2mFwaNTafoma98vz78V-7xHyHm4sevIkkEPJAlbzMhDDKg5SYJnlPEukyTM7_pYenLAvp8lpr_enG12yFAN5dWtcyf9oFW3Qq46S_QfN-pOiAd-hXxyhYRzvpGN4_apxAQKa9f2E46u3tI7dgvnCVLltdr7ufYbzDS98HZG4_7tVjU3k5Du6NPWwWamdFf_VnuHjDQO_0JWXLN38MW1n5_5NsjrTNVWMOVcYMj1v1GaNSCgrMuYLXrcXXurQCx3xq9bLuFcQYRKY_WwdqxmzNIiZqYuOScW2aeoO9yvvmlqb48pBKu7YzdCWonZTcGQrEt-07knKdHLU2exyKhcDFg68VDeL9o3Zze85hLejT1BY8YKFBcTvkfsRLJTeC3j03S8_pfnQ1Pr1_8smZ9XiH65d_RqZeTADn1_vBTT0ZPKYPHJ-Bf1oQfKE9Kr5U9I_tonJV7t0somzW-zSPj3epCxfPSNjgyRqkURVTR2SqEcSNUiiQBJdA4YCSbSDJN_xnJzs700-HQSu0EYgwwzPVDIs4xHnKU-45KMskuBxdV2GWZbo9H91HYkYRFuUdQqPV8pKZpXO-iRkPuISLsALsjVX8-oloSKqUqHXghkHExfwXkclSFLNZR5y_N4m_fUdKy5tPpXiVs1sk9zeTz_MPWadYbEb67t0pCIMw6u7XuQ1ebjB8xuytWza6i1I5lK8M4D4CzhBgrY
link.rule.ids 315,783,787,27938,27939
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Color+Change+of+Various+Medicines+under+LED+Lighting+and+Fluorescent+Lighting&rft.jtitle=Iryo+yakugaku&rft.au=Yamashita%2C+Shuji&rft.au=Noguchi%2C+Yoshihiro&rft.au=Kubota%2C+Masafumi&rft.au=Iguchi%2C+Kazuhiro&rft.date=2015-03-10&rft.issn=1346-342X&rft.eissn=1882-1499&rft.volume=41&rft.issue=3&rft.spage=198&rft.epage=204&rft_id=info:doi/10.5649%2Fjjphcs.41.198&rft.externalDBID=n%2Fa&rft.externalDocID=10_5649_jjphcs_41_198
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1346-342X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1346-342X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1346-342X&client=summon